Synthesis, characterization, anti-microbial and anti-fungal activity studies of four novel2-aminopyridine and 2,4-dichloro-5-sulfamoylbenzoic acid salts and their Cu(II) complexes
Joint Authors
Ilkimen, Halil
Gulbandilar, Aysel
Source
Issue
Vol. 50, Issue 3 A (31 Jul. 2023), pp.1-11, 11 p.
Publisher
Kuwait University Academic Publication Council
Publication Date
2023-07-31
Country of Publication
Kuwait
No. of Pages
11
Main Subjects
Abstract EN
Four novel proton transfer compounds (1-4) obtained between 2-aminopyridine (1), 2-amino-4 methylpyridine (2), 2-amino-5-methylpyridine (3), 2-amino-6-methylpyridine (4) and 2,4 dichloro-5-sulfamoylbenzoic acid (Hsba) and their Cu(II) complexes (6-10) have been synthesized.
the structures of powdery salts (1-4) and complexes (6-10) have been suggested by spectral (¹H-NMR, FT-IR and UV-Vis), elemental analysis, AAS, molar conductivity and magnetic susceptibility techniques of 6-10 have also been reported.
the structures of metal complexes (6-10) were observed octahedral according to spectroscopic analysis results.
additionally, anti-microbial and anti-fungal activities of all compounds have been tested against Escherichia coli (ATCC 25922) (Gram negative), Enterococcus faecalis (ATCC 29212) (Gram positive), staphylococcus aureus (ATCC 29213) (Gram positive), and candida albicans (ATCC 14053) (yeast), candida parapisilosis (ATCC 22019) (yeast), and candida krusei (ATCC 6258) (yeast).
the results were comparisoned with the antibiotics, fluconazole as anti-fungal agent and cefepime, levofloxacin, vancomycin as anti-microbial agents.
activity against all compounds bacteria and yeasts was observed.
therefore, all compounds may be utilized for the synthesis of new anti-microbial and anti-fungal.
compounds with the best activity are 2 (15.60 µg/mL) for S.
aureus, 2, 8 and 11 (31.25 µg/mL) for E.
Faecalis, 2a5mp, 1, 2 and 9 (31.25 µg/mL) for E.
Coli, Cu(OAc)2.2H₂O, 1, 2 and 9 (31.25 µg/mL) for C.
parapsilosis, hsba (15.60 µg/mL) for C.
albicans and Hsba and 8 (31.25 µg/mL) for C.
Krusei.
American Psychological Association (APA)
Ilkimen, Halil& Gulbandilar, Aysel. 2023. Synthesis, characterization, anti-microbial and anti-fungal activity studies of four novel2-aminopyridine and 2,4-dichloro-5-sulfamoylbenzoic acid salts and their Cu(II) complexes. Kuwait Journal of Science،Vol. 50, no. 3 A, pp.1-11.
https://search.emarefa.net/detail/BIM-1501360
Modern Language Association (MLA)
Ilkimen, Halil& Gulbandilar, Aysel. Synthesis, characterization, anti-microbial and anti-fungal activity studies of four novel2-aminopyridine and 2,4-dichloro-5-sulfamoylbenzoic acid salts and their Cu(II) complexes. Kuwait Journal of Science Vol. 50, no. 3 A (Jul. 2023), pp.1-11.
https://search.emarefa.net/detail/BIM-1501360
American Medical Association (AMA)
Ilkimen, Halil& Gulbandilar, Aysel. Synthesis, characterization, anti-microbial and anti-fungal activity studies of four novel2-aminopyridine and 2,4-dichloro-5-sulfamoylbenzoic acid salts and their Cu(II) complexes. Kuwait Journal of Science. 2023. Vol. 50, no. 3 A, pp.1-11.
https://search.emarefa.net/detail/BIM-1501360
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 9-11
Record ID
BIM-1501360