Nimesulide derivatives reduced cell proliferation against breast and ovarian cancer : synthesis, characterization, biological assessment, and crystal structure
Joint Authors
Ali, Mayadah S.
Jaragh al-Hadad, Layla A.
Source
Issue
Vol. 49, Issue 3 (31 Jul. 2022), pp.1-17, 17 p.
Publisher
Kuwait University Academic Publication Council
Publication Date
2022-07-31
Country of Publication
Kuwait
No. of Pages
17
Main Subjects
Abstract EN
New nimesulide derivatives (A1-A6) were synthesized and investigated by IR, 1 H NMR, 13C NMR, melting point, elemental analysis, mass spectra, and DSC analysis.
Agent A3 single crystal was grown and solved in a monoclinic crystal system with Cc.
Heat shock protein 27 (HSP27) and tubulin are essential cellular proteins for normal cell division and growth.
In addition, these proteins are expressed highly in cancer cells.
Breast cancer (SKBR3) and ovarian cancer (SKOV3) cell lines are our models for biological assessment.
The data revealed that nimesulide analogs showed high cytotoxicity when treated with SKBR3 cell line ranges from 0.22 µM to 12.0 µM, while SKOV3 cell line from 0.1 µM to 16.0 µM.
In-depth, structure-activity relationship applied to nimesulide lead structure highlights the importance of a bulk moiety in position two that reduces cell proliferation in both cell lines.
American Psychological Association (APA)
Jaragh al-Hadad, Layla A.& Ali, Mayadah S.. 2022. Nimesulide derivatives reduced cell proliferation against breast and ovarian cancer : synthesis, characterization, biological assessment, and crystal structure. Kuwait Journal of Science،Vol. 49, no. 3, pp.1-17.
https://search.emarefa.net/detail/BIM-1502761
Modern Language Association (MLA)
Jaragh al-Hadad, Layla A.& Ali, Mayadah S.. Nimesulide derivatives reduced cell proliferation against breast and ovarian cancer : synthesis, characterization, biological assessment, and crystal structure. Kuwait Journal of Science Vol. 49, no. 3 (Jul. 2022), pp.1-17.
https://search.emarefa.net/detail/BIM-1502761
American Medical Association (AMA)
Jaragh al-Hadad, Layla A.& Ali, Mayadah S.. Nimesulide derivatives reduced cell proliferation against breast and ovarian cancer : synthesis, characterization, biological assessment, and crystal structure. Kuwait Journal of Science. 2022. Vol. 49, no. 3, pp.1-17.
https://search.emarefa.net/detail/BIM-1502761
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 14-17
Record ID
BIM-1502761