Prognostic significance of p53 expression in breast carcinoma

Abstract EN

Background & Aim : Breast cancer is the most frequently diagnosed cancer among females worldwide.

p53 tumor suppressor gene regulates the cell cycle and DNA repair and its over expression in breast carcinoma is associated with a worse prognosis.

The aims of the our study are; first, to determine the frequency of p53 overexpression in different types of infiltrating breast carcinoma.

Second, to study the correlation between the p53 over-expression with different parameters, including the age, size, grade, histologic type.

the status of lymph nodes, CD10 expression.

Third, to compare our results with others Methods : The study included 100 cases of breast carcinoma.

Data were obtained from archives of the pathology department, at AL-Assad University Hospital in 2017 .p53 over-expression was assessed immunohistochemically..

Results : The patients ages ranged from 33 to 79 years ,most of them were in the fifth decade (32%).

There was a significant positive relation between p53 over-expression and K167 expresssion (P=0.000), and HER2/neu (P-0.038).

There was a significant direct correlation between p53 over-expression and molecular classification (p=0.000), grade (p=0.002), axillary lymph node metastasis (p=0.000) and CD10 expression(p=0.000).

p53 over-expression was found in (100%) of micropapillary carcinoma, (93.3%) of invasive breast carcinoma (NST), (50%) of invasive cribriform, and (53.3%) of invasive lobular carcinoma.

Conclusions : p53 over-expression was significantly correlated with pathologic parameters refer to worse prognosis, so p53 overexpression was found to be poor prognostic factor and its detection may help in risk catergorization and designing future target approaches.