Green synthesis and spectroscopic study of new heterocyclic compounds derived from ethyl coumarilate
Joint Authors
Khalaf, Karam A.
Umar, Adnan O.
Source
African Journal of Advanced Pure and Applied Sciences
Issue
Vol. 2, Issue 2 (30 Apr. 2023), pp.281-289, 9 p.
Publisher
African Academy of Advanced Studies
Publication Date
2023-04-30
Country of Publication
Libya
No. of Pages
9
Main Subjects
Abstract EN
The common starting compound ethyl coumarilate and substituted (1,2,3) prepared by the reaction of substituted salicylaldehydes with ethyl chloroacetate in the presence of base the treatment of (1,2,3) with hydrazine hydrate give 2,3a-dihydro-3H-benzofuro[3,2-c]pr azol-3-one (4, 11&18) derivative.
But when the ester (1,2,3) reacted with phenyl hydrazine form 2-phenyl-2,3a-dihydro-3H-benzofuro[3,2-c) pyrazol-3-one (5, 12&19).
similar type of reaction occurs with urea, thiourea, guanidine, semicarbazide, thiosemicarbazide, to produce benzofuro [3,2-d] pyrimidine-2,4(3H,4aH)-Dione (6, 13&20).
2-thioxo-2,4a-dihydrobenzofuro [3,2-d] pyrimidin-4(3H)-one (7, 14&21).
2-imino-2,4a-dihydrobenzofuro [3,2-d] pyrimidin-4(3H)-one (8, 15&22), 3-oxo-3,3a-dihydro-2H-benzofuro [3, 2-c] pyrazole-2-carboxamide (9, 16&23), 3-oxo-3,3a-dihydro-2H-benzofuro[3,2-c] pyrazole-2-carbothioamide (10, 17&24) derivatives were synthesized in good to excellent yield under ultrasonic irradiation.
the structures of all synthesized compounds in this study have been established by using FT-IR, 1H NMR, and 13C NMR techniques.
American Psychological Association (APA)
Khalaf, Karam A.& Umar, Adnan O.. 2023. Green synthesis and spectroscopic study of new heterocyclic compounds derived from ethyl coumarilate. African Journal of Advanced Pure and Applied Sciences،Vol. 2, no. 2, pp.281-289.
https://search.emarefa.net/detail/BIM-1508464
Modern Language Association (MLA)
Khalaf, Karam A.& Umar, Adnan O.. Green synthesis and spectroscopic study of new heterocyclic compounds derived from ethyl coumarilate. African Journal of Advanced Pure and Applied Sciences Vol. 2, no. 2 (Apr. / Jun. 2023), pp.281-289.
https://search.emarefa.net/detail/BIM-1508464
American Medical Association (AMA)
Khalaf, Karam A.& Umar, Adnan O.. Green synthesis and spectroscopic study of new heterocyclic compounds derived from ethyl coumarilate. African Journal of Advanced Pure and Applied Sciences. 2023. Vol. 2, no. 2, pp.281-289.
https://search.emarefa.net/detail/BIM-1508464
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 288-289
Record ID
BIM-1508464