دراسة مستويات هابتوغلوبين المصل عند عينة من السوريين المصابين بالنمط الثاني من الداء السكري مع أمراض القلب الإقفارية و دونها

Abstract EN

Background & Aim : DM shares with IHD several pathogenic mechanisms such as insulin resistance, inflammatory state and oxidative stress, which in turn leads to lipid peroxidation (a form of oxidative stress expression) that may contribute to inflammation and atherosclerosis.

The role of Hp, which reduces free radical formation and the occurrence of oxidative stress, was studied as a risk factor for IHD.

Tis study Aim To investigate the Hp levels changes in type 2 diabetes, and to investigate the relationship of these changes to IHD (myocardial infarction - coronary arterial disease) and their inflammatory and metabolic risk factors in a Syrians sample.

Materials and Methods : An observational study of the case-control group included 70 participants who were distributed into three groups (14 individuals within the control group, 28 individuals within the diabetic group without an IHD, and 28 individuals within the diabetic group with an IHD).

The samples were collected in the internal medicine department at Al-Mouwasat University Hospital in Damascus between 15/07/2020 and 30/12/2020.

The Hp levels of the three groups were evaluated in the laboratory medicine department of the same hospital.

Results : The serum Hp mean in diabetic group without an IHD was (45.64 +23.92) and with an IHD was (73.42±37.67) significantly higher in control group (18.52 ± 8.91).

Hp mean in diabetic group with an IHD was significantly higher in diabetic group without an IHD.

There was significant correlation between Hp and CRP in both groups (without and with IHD).

Conclusion : the study revealed association between increased serum Hp levels in diabetic patients and IHD development.

Thus, it can be considered as risk factor for IHD development in T2DM.