Synergistic effect of capparis spinosa fruits extract in comparison with ciprofloxacin against resistant e. coli o157 : h7
Joint Authors
al-Rida, Riham Najm Abd
Salim, Ali H.
Source
Journal of Thi-Qar University for Agricultural Researches
Issue
Vol. 11, Issue 2 (31 Dec. 2022), pp.172-186, 15 p.
Publisher
University of Thi-Qar College of Agricultural and Marshes
Publication Date
2022-12-31
Country of Publication
Iraq
No. of Pages
15
Main Subjects
Abstract EN
This study was conducted to evaluate the synergistic effect between Capparis Spinosa fruits methanolic extract and ciprofloxacin against resistant E.
Coli O157 : H7, in varying concentration.
This experiment was carried out through the ultrasonic alcoholic extraction of C.
Spinosa fruits, and an extraction ratio of 24% was obtained.
The extract showed pronounced concentration dependent antibacterial activity.
The susceptibility study revealed that E.
Coli O157 : H7 was sensitive to C.
Spinosa fruits.
The findings of the present study indicate that the use of pronounced C.
Spinosa fruits extract may have the perfect to be choice in clinical control.
The concentration of C.
spinosa fruits extract increase the activity of inhibition, increase as well when used in combination with ciprofloxacin (half concentration from each other).
In result appeared synergism effect between plant extract and ciprofloxacin and may make bacteria lost their resistance to antibiotics by this synergism phenomenon.
The result of MIC (6400 µg/ ml), MBC (12800 µg/ ml) and for C.
spinose fruits extract while ciprofloxacin MIC (12.5 µg/ml) and MBC (25 µg/ml).
MICs of CIP/ C.
spinosa fruits extract combinations against E.
coli 0157 : H7 isolate was 1.562/ 1600 µg/ml.
Value of minimum bactericidal concentration (MBC) of the synergistic combinations (CIP) C.
spinosa fruits extract) was 3.124/ 3200 µg/mlAccording to obtained results fractional inhibitory concentration (FIC) value of (CIP/ C.
spinosa fruits extract 1.562/ 1600 µg/ml) was (0.375) less than 0.5 indicates synergistic effect of interaction.
American Psychological Association (APA)
al-Rida, Riham Najm Abd& Salim, Ali H.. 2022. Synergistic effect of capparis spinosa fruits extract in comparison with ciprofloxacin against resistant e. coli o157 : h7. Journal of Thi-Qar University for Agricultural Researches،Vol. 11, no. 2, pp.172-186.
https://search.emarefa.net/detail/BIM-1513606
Modern Language Association (MLA)
al-Rida, Riham Najm Abd& Salim, Ali H.. Synergistic effect of capparis spinosa fruits extract in comparison with ciprofloxacin against resistant e. coli o157 : h7. Journal of Thi-Qar University for Agricultural Researches Vol. 11, no. 2 (2022), pp.172-186.
https://search.emarefa.net/detail/BIM-1513606
American Medical Association (AMA)
al-Rida, Riham Najm Abd& Salim, Ali H.. Synergistic effect of capparis spinosa fruits extract in comparison with ciprofloxacin against resistant e. coli o157 : h7. Journal of Thi-Qar University for Agricultural Researches. 2022. Vol. 11, no. 2, pp.172-186.
https://search.emarefa.net/detail/BIM-1513606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 18-186
Record ID
BIM-1513606