Effect of cloves (Syzygium Aromaticum)‎ on serum biomarkers of some common complications and oxidative stress on Alloxan-induced diabetic rats

Abstract EN

Objectives: this research aimed to find out the potential effect of cloves (Syzygium Aromaticum) on hyperglycemia, hyperlipidemia, hepatorenal disorders and oxidative stress as the known complications related to diabetes.

materials and methods: forty male rats were divided into 5 groups (N= 8), including the healthy control group (NC) and four diabetic groups.

Alloxan-monohydrate (BDH) was used for prompting diabetes (100 MG / KG B.W.).

rats with diabetes were put into a control group (DC), diabetic treated with clove oil (200 MG \ KG) (G3), clove extract (200 MG \ KG) (G4) and clove powder (20 G \ KG) (G5).

after 4 weeks of the treatment, the blood samples were taken for measuring the fasting blood glucose, insulin, lipid profiles, liver and kidney functions and some antioxidant / oxidative stress markers.

results: the therapeutic groups (clove oil, extract and powder) statistics had low levels of fasting blood sugar, total cholesterol, LDL-c, VLDL-c, triglycerides, AST, ALT, urea, uric acid, creatinine, bilirubin and MDA in comparison with the dc group.

contrarily, serum insulin levels, HDL-c, sod and GSH actually were higher in the clove oil, extract and powder groups compared to the dc group.

conclusion: it could be concluded that the clove oil or extract or powder proved antioxidant qualities and has potential as a functional food ingredient to protect against the complications caused by diabetes.