The diagnostic value of serological markers for the diagnosis of gluten sensitive enteropathy in Syria
Other Title(s)
القيمة التشخيصية للواسمات المصلية في الاعتلال المعوي التحسسي للغلوتن في سوريا
Joint Authors
Jumah, Muhyi Din
Sitzmann, Fredrich Carl
Seferian, Vahe
Ghamyan, Firas
al-Hamawi, Adnan Hasan
Khuri, Lina
Source
Journal of the Arab Board of Health Specializations
Issue
Vol. 2, Issue 2 (30 Apr. 2000), pp.85-90, 6 p.
Publisher
The Arab Board of Health Specializations
Publication Date
2000-04-30
Country of Publication
Syria
No. of Pages
6
Main Subjects
Abstract EN
Objectives : Analyzing the diagnostic efficacy of three serological markers of celiac disease: IgA anti-gliadin (AGA- IgA), IgG anti-gliadin (AGA-IgG), and IgA anti-endomysium (EMA-IgA) antibodies.
Methods :We studied 64 serum samples from 3 groups of patients: celiac patients on a gluten- challenge diet, celiac patients on a gluten-free diet, and a control group.
All individuals assayed were from the Gastroenterology Section of the Children's University Hospital and the Assad University Hospital in Damascus, Syria.
: Result;The anti-gliadin and anti-endomysium antibody levels were significantly higher among the gluten- consuming celiac patients than in the other groups.
The greatest efficacy in diagnosing celiac disease was achieved in the EMA-class test.
The IgG-class anti-gliadin antibodies were more specific, with a higher positive test predictive value than the IgA-class anti-gliadin antibodies, whereas the latter showed to be more sensitive, with a higher negative test predictive value.
Conclusion : Our results also demonstrate that the simultaneous assessment of anti-gliadin IgA- and IgG-class antibodies constitutes a valid method of selecting patients suspected of having celiac disease.
In turn, the assessment of EMA-IgA antibodies constitutes a confirmative test for indication for intestinal biopsy.
American Psychological Association (APA)
Seferian, Vahe& al-Hamawi, Adnan Hasan& Khuri, Lina& Sitzmann, Fredrich Carl& Jumah, Muhyi Din& Ghamyan, Firas. 2000. The diagnostic value of serological markers for the diagnosis of gluten sensitive enteropathy in Syria. Journal of the Arab Board of Health Specializations،Vol. 2, no. 2, pp.85-90.
https://search.emarefa.net/detail/BIM-153884
Modern Language Association (MLA)
Ghamyan, Firas…[et al.]. The diagnostic value of serological markers for the diagnosis of gluten sensitive enteropathy in Syria. Journal of the Arab Board of Health Specializations Vol. 2, no. 2(April 2000), pp.85-90.
https://search.emarefa.net/detail/BIM-153884
American Medical Association (AMA)
Seferian, Vahe& al-Hamawi, Adnan Hasan& Khuri, Lina& Sitzmann, Fredrich Carl& Jumah, Muhyi Din& Ghamyan, Firas. The diagnostic value of serological markers for the diagnosis of gluten sensitive enteropathy in Syria. Journal of the Arab Board of Health Specializations. 2000. Vol. 2, no. 2, pp.85-90.
https://search.emarefa.net/detail/BIM-153884
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 90
Record ID
BIM-153884