Spectrophotometric determination of methyldopa in pure and pharmaceutical preparations by the oxidative coupling reaction with 1, 5-diaminonaphthalene in the presence of ammonium ceric (iv) nitrate
Other Title(s)
التقدير الطيفي للمثيل دوبا بواسطة تفاعل الاقتران التأكسدي مع الكاشف -51 ثنائي امينو نفثالين بوجود العامل المؤكسد نترات السيريك الامونياكي
Joint Authors
Ghib Allah, Nur Mansur
Ahmad, Abd al-Majid Khurshid
Tapabashi, Nashwan Umar Rashid
Source
Kirkuk University Journal-Scientific Studies
Issue
Vol. 17, Issue 4 (31 Dec. 2022), pp.41-48, 8 p.
Publisher
Kirkuk University College of Science
Publication Date
2022-12-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Arts & Humanities (Multidisciplinary)
Abstract AR
تتضمن الدراسة تطوير طريقة طيفية سريعة وحساسة لتقدير كميات ضئيلة من المثيل دوبا في محلول مائي حامضي، تعتمد الطريقة على الاقتران التأكسدي للعقار مع الكاشف 5.1 ثنائي امينو نفثالين بوجود العامل المؤكسد نترات السيريك الأمونياك لتكوين ناتج ازرق اللون ذائب بالماء مستقر، يعطي أعلى امتصاص عند الطول الموجي 730 نانوميتر ويخضع لقانون بير بحدود (39.6 5.4) مايكرو غرام وبلغت الامتصاصية المولارية 10 × 4.79471 لتر مول سم، ودلالة ساندل 0.0044 مايكرو غرام / سم الانحراف القياسي النسبي بين (0.5942 -0,9687) ومعدل الاسترجاعية %99.908 ، معامل التقدير 0.9998 وطبقت هذه الطريقة المقترحة بنجاح التقدير المثيل دوبا في مستحضراته الدوائية.
Abstract EN
Oxidative coupling reactions are one of the significant methods used in the estimation of certain drugs in pharmaceutical formulations.
This study describes the development of a fast and sensitive spectroscopic method considering the determination of trace amounts of methyldopa in an acidic aqueous solution.
The adopted method centered on oxidative coupling due to the drug Methyldopa with the reagent 1, 5-diaminonaphthalene in the presence of ceric (IV) ammonium nitrate as oxidizing agent to form a stable blue-colored product, giving the highest absorption at 730 nm.
The product was appeared to agree Beer's law within the limits of (5.4-39.6) μg /ml, and a value of molar absorptivity equal to 4.79471x10 L /mol.cm.Sandell'sindex, 0.0044μg/ cm², Relative standard deviation was in the range (0.5942 -0.9687) %, whereas recovery average and determination factor were 99.908% and 0.9998.
The proposed method has been successfully applied in the determination of Methyldopa in its pharmaceutical preparations.
American Psychological Association (APA)
Ghib Allah, Nur Mansur& Ahmad, Abd al-Majid Khurshid& Tapabashi, Nashwan Umar Rashid. 2022. Spectrophotometric determination of methyldopa in pure and pharmaceutical preparations by the oxidative coupling reaction with 1, 5-diaminonaphthalene in the presence of ammonium ceric (iv) nitrate. Kirkuk University Journal-Scientific Studies،Vol. 17, no. 4, pp.41-48.
https://search.emarefa.net/detail/BIM-1547479
Modern Language Association (MLA)
Ghib Allah, Nur Mansur…[et al.]. Spectrophotometric determination of methyldopa in pure and pharmaceutical preparations by the oxidative coupling reaction with 1, 5-diaminonaphthalene in the presence of ammonium ceric (iv) nitrate. Kirkuk University Journal-Scientific Studies Vol. 17, no. 4 (2022), pp.41-48.
https://search.emarefa.net/detail/BIM-1547479
American Medical Association (AMA)
Ghib Allah, Nur Mansur& Ahmad, Abd al-Majid Khurshid& Tapabashi, Nashwan Umar Rashid. Spectrophotometric determination of methyldopa in pure and pharmaceutical preparations by the oxidative coupling reaction with 1, 5-diaminonaphthalene in the presence of ammonium ceric (iv) nitrate. Kirkuk University Journal-Scientific Studies. 2022. Vol. 17, no. 4, pp.41-48.
https://search.emarefa.net/detail/BIM-1547479
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 46-47
Record ID
BIM-1547479
