Anticancer effects & comparative study of thymoquinone, cordyceps, spirulina, ganoderma lucidium, poria cocos, and lion's mane on human nasal cancer cells (RPMI-2650)‎

Abstract EN

Recently, many studies have been conducted to discover or improve cancers treatment.

The current study aims to investigate the anticancer effect of thymoquinone, cordyceps, spirulina, ganoderma lucidium, poria cocos, and lion's mane in four different concentrations 4, 8, 16, and 32 ug (equivalent to 1 mg/mL) in two different time treatments (48 and 96 hours) on human nasal epithelial cell line RPMI 2650.

By using cell culture cytotoxicity techniques and assay, the highest anticancer effect on RPMI 2650 was obtained by thymoquinone.

the lowest anticancer effect was demonstrated by poria cocos and cordyceps.

however, these two medications showed higher anticancer effect when given in short-term treatment (48 hours) compared to long-term treatment (96 hours).

ganoderma lucidium and spirulina showed better impact than poria cocos, cordyceps, and lion's mane in term of cells cytotoxicity.

mild to moderate antineoplastic effect was seen by utilizing lion's mane treatment compared other drugs.

therefore, adopting a long- term treatment of high concentrations and doses of thymoquinone, cordyceps, spirulina, ganoderma lucidium, poria cocos, and lion's mane can be more effective in the treatment of nasal cancer.

in conclusion, these drugs were found to be a promising cancer remedy; therefore, they can be utilized as alternative treatment for nasal cancer or any other type of cancer therapy.