Helicobacter Pylori treatment regimen and the extent of antibiotics effectiveness in AL- Gamhoria teaching Hospital and five private clinics in Aden-Yemen, 2017

Abstract EN

Studies about H pylori infection in Aden governorate are still scarce.

Thus, our objectives in this study are to investigate and to evaluate the incidence rate of H.

pylori infection, risk factors, efficacy of therapy and drug resistance.

A cross sectional study was conducted for 325 patients who attended in Al-Gamhuria Teaching Hospital and five private clinics, in Aden governorate, during the period March to September - 2017.

Gastric mucosa biopsy samples were obtained from 50 patients who had undergone upper gastrointestinal endoscopy for culture and sensitivity test for H.

pylori for susceptibility to four antibiotics (clarithromycin, amoxicillin, metronidazole, and levofloxacin).

During this study, we found that (70.8%) females and (29.2%) males are suffering from H.

pylori infection.

The maximum number of cases (41.2%) were found between the age group 21-30 years.

59.4% of them received (PPI+ Clarithromycin+ Amoxicillin or metronidazole), while 40.6% received (Levofloxacin containing triple therapy) for 10-14 days.

25.2% have been completely improved, and 3.4% haven't, while 30.2% have recurrent, 41.2% not return for farther follow up.

All risk factors are in higher percentage.

The commonest drug resistant for Amoxicillin was 30%, Clarithromycin 26% and metronidazole was 24%., while 20% for Levofloxacin.

Conclusion: To eradicate H.

pylori successfully, the whole society authorities and systems should cooperate together as one team because this is multifactor problem, including host, environmental, socioeconomic, educational and inappropriate treatment.