Association of CYP19 gene polymorphism with breast cancer in Iraqi women
Other Title(s)
علاقة تعدد الاوجه لجين (CYP19) مع سرطان الثدي في النساء العراقيات
Author
Source
Journal of Babylon University : Journal of Applied and Pure Sciences
Issue
Vol. 30, Issue 1 (31 Mar. 2022), pp.161-169, 9 p.
Publisher
Publication Date
2022-03-31
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Topics
Abstract AR
الانزيم الاساسي في عمليه تصنيع هرمون الاستروجين بواسطة انزيم الاوروماتيز والذي يكون مسيطر عليه من قبل جين السي واي بى 19 اي وان، وعليه فان نشاط هذا الهرمون له علاقة مباشره بحالات سرطان الثدي.
من خلال البحث الذي اجريناه فى مجموعه مكونه من 45 امرأة في محافظه كربلاء اظهر بان جين السي واي جي 19المتعدد الاوجه من النيكليوتايد وهذا ناتج عن النشاط المتزايد من هرمون الاستروجين فى نسيج الثدي.
بالاعتماد على قياس البي ام اى فان المجموعة ذات <20 يظهر بان 22.2% مصابه بسرطان الثدي مقارنه ب 30% غير مصابه.
في حاله البي ام اي (20-24) فان22.2% اصابه بسرطان الثدي مقارنه ب 20% غير مصابه.
اما في البي ام اي>24 فان 22.2% اصابه بسرطان الثدي مقابل 30% غير مصابه.
التحليل الجزيئي يظهر بان اليل اي التابع لجين سي واي بي جي 19 كان تردده (0.6333) مقارنه ب اليل ج بتردد (0.3667)، وهذا يعنى بان عدد الاصابات بسرطان الثدي يكون 28 و17 بالتتابع ولكلا المجموعتين من أصل 45 حاله.
وهذا دليل على اهميه الاوجه المتعددة لجين السي واي بي جي.
Abstract EN
The basic enzyme in estradiol synthesis is, Aromatase, it is encoded by the gene called CYP19A1.
Given the importance of estrogen in the development of Breast cancer risk, we studyt genetic polymorphisms in the CYP19A1 gene the, including rs10046, in a group of 45 patient women in Kerbala province, Iraq.
Our aim to investigate CYP19AI polymorphism its impact on patients of Breast cancer in Iraqi women.
We found in our study, that in Iraqi postmenopausal women,( rs10046) single nucleotides and polymorphism (SNPs) was prognostic of different levels of estrone and Estradiol.
Depending on the BMI scale reveals 22.25% with the breast cancer group in Comparison with 30% of healthy women.
In case of BMI with( 20-24) in the breast cancer group were 22.2% compared with the healthy group 20%., While BMI of >24 we found 33.4% in case of Breast cancer affected group in comparison with 20% of the unaffected group (Healthy).
While in case of BMI >30 there were 22.2% in case of the Breast cancer group in comparison with 30% of unaffected (healthy) group.
The molecular analysis of CYP19 gene ,reveals that A allele frequency was (0.6333) and G allele (0.3667) upon that, we found that the number of patients which have had breast cancer were 28 and 17 ,respectively.
In summary, our data show that polymorphisms in the CYP19A1 gene may contribute to Breast carcinogenesis in Iraqi women
American Psychological Association (APA)
al-Zahid, Abd al-Amir Ali. 2022. Association of CYP19 gene polymorphism with breast cancer in Iraqi women. Journal of Babylon University : Journal of Applied and Pure Sciences،Vol. 30, no. 1, pp.161-169.
https://search.emarefa.net/detail/BIM-1592367
Modern Language Association (MLA)
al-Zahid, Abd al-Amir Ali. Association of CYP19 gene polymorphism with breast cancer in Iraqi women. Journal of Babylon University : Journal of Applied and Pure Sciences Vol. 30, no. 1 (2022), pp.161-169.
https://search.emarefa.net/detail/BIM-1592367
American Medical Association (AMA)
al-Zahid, Abd al-Amir Ali. Association of CYP19 gene polymorphism with breast cancer in Iraqi women. Journal of Babylon University : Journal of Applied and Pure Sciences. 2022. Vol. 30, no. 1, pp.161-169.
https://search.emarefa.net/detail/BIM-1592367
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references: p. 168-169
Record ID
BIM-1592367