Blockage of alzheimer’s gene: breakthrough effect of apolipoprotein e4
Joint Authors
Adetuyi, Babatunde Oluwafemi
Olajide, Peace Abiodun
Omowumi, Oluwakemi Semiloore
Odine, Grace Onuwabhagbe
Okunlola, Darasimi Deborah
Taiwo, Anjolaoluwa Maryann
Opayinka, Oluwaseun Dorcas
Source
African Journal of Advanced Pure and Applied Sciences
Issue
Vol. 1, Issue 3 (31 Aug. 2022), pp.26-33, 8 p.
Publisher
African Academy of Advanced Studies
Publication Date
2022-08-31
Country of Publication
Libya
No. of Pages
8
Main Subjects
Abstract EN
One of the essential hereditary hazard factors for AD (Alzheimer’s Disease) is the existence of APOE (Apolipoprotein E4 allele).
Multivariate lipoprotein called APOE happens to be crucial for the movement of cholesterol in the brain.
Along with other things, it has a crucial function in the breakdown of glucose, neuro-inflammation, and neuronal signaling.
The 3 Apolipoprotein allele variants include E2, E3, and E4.
The most occurring allele in humans is the E3 allele.
The risk of Alzheimer’s disease is connected to the E4 allele being higher, but the E2 allele is connected with a slighter risk.
Building cellular and animal models has taken a lot of effort in order to comprehend the molecular processes behind APOE-related genetic risk.
Results from these concepts suggest that APOE4 may increase tau development of disease in a manner similar to that of isoform-dependent and that it aggravates amyloid plaque load in a manner similar to dose-dependent.
American Psychological Association (APA)
Adetuyi, Babatunde Oluwafemi& Olajide, Peace Abiodun& Omowumi, Oluwakemi Semiloore& Odine, Grace Onuwabhagbe& Okunlola, Darasimi Deborah& Taiwo, Anjolaoluwa Maryann…[et al.]. 2022. Blockage of alzheimer’s gene: breakthrough effect of apolipoprotein e4. African Journal of Advanced Pure and Applied Sciences،Vol. 1, no. 3, pp.26-33.
https://search.emarefa.net/detail/BIM-1594319
Modern Language Association (MLA)
Adetuyi, Babatunde Oluwafemi…[et al.]. Blockage of alzheimer’s gene: breakthrough effect of apolipoprotein e4. African Journal of Advanced Pure and Applied Sciences Vol. 1, no. 3 (Aug. 2022), pp.26-33.
https://search.emarefa.net/detail/BIM-1594319
American Medical Association (AMA)
Adetuyi, Babatunde Oluwafemi& Olajide, Peace Abiodun& Omowumi, Oluwakemi Semiloore& Odine, Grace Onuwabhagbe& Okunlola, Darasimi Deborah& Taiwo, Anjolaoluwa Maryann…[et al.]. Blockage of alzheimer’s gene: breakthrough effect of apolipoprotein e4. African Journal of Advanced Pure and Applied Sciences. 2022. Vol. 1, no. 3, pp.26-33.
https://search.emarefa.net/detail/BIM-1594319
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references: p. 31-33
Record ID
BIM-1594319