The impact of hepatitis C infection and antiviral therapy on clinical outcome in renal transplantation recipients
Joint Authors
Rashid, Awwad
Abbud, Umar Ibrahim
Taha, Mustafa
al-Sayyid, Muhammad
al-Kabi, Sad
Ashur, Adil M.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 10, Issue 1 (28 Feb. 1999), pp.31-35, 5 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
1999-02-28
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Topics
- Patients
- Kidneys
- Virus diseases
- Chemotherapy
- Antiviral agents
- Therapeutics
- Organ transplantation
- Hepatitis C
Abstract EN
Hepatitis C viral infection (HCV) is presently a major problem in renal transplant recipients (RTR) with a high risk of chronicity resulting in liver cirrhosis.
We screened 120 RTR (50 live related, 53 live unrelated, and 17 cadaveric); mean age of 45.2 years and mean post-transplant period of 6.8 years.
Positive HCV antibodies using RIBA-2 test were detected in 43 patients (35.8%).
Polymerase chain reaction was performed on 37 seropositive patients and confirmed viremia in 100% of hem.
Forty-one seropositive patients (95.3%) had previous dialysis prior to transplantation; a mean of 4.5 years.
Liver disease manifested in only five (11.6%) of the seropositive patients and hypertransaminasemia was detected in 14 (32.6%).
Twelve seropositive patients with elevated transaminase levels and/or clinical evidence of liver disease, who all had positive PCR, underwent liver biopsy.
Inflammation restricted to portal area was noticed in two, persistent hepatitis in three, chronic active hepatitis in four and cirrhosis in three.
There was significantly higher incidence (P<0.03) of acute graft rejection in the seropositive (23.3%) compared to the seronegative patients (9.1% ).
While the difference did not amount to statistical significance for chronic rejection (9.3% and 6.5% respectively).
Two patients had acute cellular rejection related to interferon therapy.
The leading cause of death was related to liver failure in the seropositive patients and coronary artery disease in he seronegative RTR.
In conclusion, there is high incidence of HCV in or renal transplant recipients associated with relatively high morbidity and mortality.
At present we are lacking an efficient and welltolerated antiviral drug
American Psychological Association (APA)
Rashid, Awwad& Abbud, Umar Ibrahim& al-Kabi, Sad& Taha, Mustafa& Ashur, Adil M.& al-Sayyid, Muhammad. 1999. The impact of hepatitis C infection and antiviral therapy on clinical outcome in renal transplantation recipients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 10, no. 1, pp.31-35.
https://search.emarefa.net/detail/BIM-161481
Modern Language Association (MLA)
Rashid, Awwad…[et al.]. The impact of hepatitis C infection and antiviral therapy on clinical outcome in renal transplantation recipients. Saudi Journal of Kidney Diseases and Transplantation Vol.20, no.3 (December 1999), pp.31-35.
https://search.emarefa.net/detail/BIM-161481
American Medical Association (AMA)
Rashid, Awwad& Abbud, Umar Ibrahim& al-Kabi, Sad& Taha, Mustafa& Ashur, Adil M.& al-Sayyid, Muhammad. The impact of hepatitis C infection and antiviral therapy on clinical outcome in renal transplantation recipients. Saudi Journal of Kidney Diseases and Transplantation. 1999. Vol. 10, no. 1, pp.31-35.
https://search.emarefa.net/detail/BIM-161481
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 34-35
Record ID
BIM-161481