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Pathogenesis of acute renal failure: shock-kidneys
Author
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 9, Issue 3 (30 Jun. 1998), pp.231-236, 6 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
1998-06-30
Country of Publication
Saudi Arabia
No. of Pages
6
Main Subjects
Topics
Abstract EN
Causes of acute renal failure (ARF) are summarized.
The article focuses on "shock kidneys" as they occur following traumatic or septic shock.
There may be low-grade intermittent but persisting endotoxemia in the former together with other factors like rhabdomyolysis, and marked endotoxemia at least for a few hours in the latter.
Endotoxin is a prime cause of release of noxious cytokines like tumor necrosis factor-alpha (TNFa).
At present, many studies support the evidence for its role in multi-organ failure (MOF).
One can account for endotoxemia along with bacterial translocation through the gastrointestinal mucosa if there is transient mesenteric ischemia during shock.
Hence, monocytemacrophages can be stimulated to release their cytokines that predispose to MOF.
The cell biology of renal tubular changes in ARF is then briefly discussed in order to mention new therapeutic approaches.
American Psychological Association (APA)
Nigel Wardle, E.. 1998. Pathogenesis of acute renal failure: shock-kidneys. Saudi Journal of Kidney Diseases and Transplantation،Vol. 9, no. 3, pp.231-236.
https://search.emarefa.net/detail/BIM-163561
Modern Language Association (MLA)
Nigel Wardle, E.. Pathogenesis of acute renal failure: shock-kidneys. Saudi Journal of Kidney Diseases and Transplantation Vol. 9, no.2 (December 1998), pp.231-236.
https://search.emarefa.net/detail/BIM-163561
American Medical Association (AMA)
Nigel Wardle, E.. Pathogenesis of acute renal failure: shock-kidneys. Saudi Journal of Kidney Diseases and Transplantation. 1998. Vol. 9, no. 3, pp.231-236.
https://search.emarefa.net/detail/BIM-163561
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 235-236
Record ID
BIM-163561