The effect of short term use of indomethacin, a non-steroidal anti-inflammatory drug, on peritoneal dialysis patients

Abstract EN

In this study, the effect of indomethacin a nonsteroidal anti-inflammatory drug (NSAID) was studied to evaluate the effect of its short-term use on peritoneal clearance of urea and creatinine as well as protein excretion in nine chronic renal failure patients on intermittent peritoneal dialysis therapy.

Four of them were males and five were females with mean age of 54.4 years.

Clearance values and protein excretion in the dialysate effluents were measured before and after administering the indomethacin.

There was no significant effect on the urea and creatinine clearance after the use of this drug.

However, the mean ± SE protein concentration in the dialysate effluents decreased significantly after the use of indomethacin from 43.1 + 4.5 to 37.0 + 3.5 mg/dl (p<0.01).

This reduction of protein excretion in the dialysate after the use of indomethacin might enhance the nutritional status of patients on peritoneal dialysis.