Effects of chlorpyrifos on the heart and blood parameters of adult

Abstract EN

-The purpose of the present study was to investigate the effect of chlorpyrifos (0.

0-diethyl-0- (3,5.6-trichloro -2-pyridiny) phosphorothionate : CPF) on the heart and blood parameters of New Zealand white adult male rabbits following administration of sub lethal dose (1500 mg/kg body weight.

Orally) on alternate days for one month.

There was no statistically significant differences in heart rate.

The P-R interval and QRS wave.

The blood parameters : packed cell volume (PCV).

Red blood cells (RBC's) count.

hemoglobin (Hb).

Mean corpuscular volume (MCV).

Mean corpuscular hemoglobin (MCH).

and mean corpuscular hemoglobin concentration (MCHC) were almost identical when compared with the control group.

however.

Chlorpyrifos treatment resulted in decreased white blood cells (WBC's) count.

The results indicate that serum electrolytes Na+.

K+ and Ca++ were also within the normal levels in control and chlorpyrifos treated groups.

These data clearly show that there is no effect of chlorpyrifos intoxification at sublethal dose of 1500 mg/kg body weight in adult mate rabbits.