Langerhans'cell histiocytosis (histiocytosis x)‎

Abstract EN

The terms Langerhans'cell histiocytosis, histio¬cytosis x, Langerhans'cell granulomatosis and eosinophilic granuloma are used for a specific but variable clinko-pathology entity that are presented by proliferation of Langerhans' cell accompanied by a variable number of eosinophils, giant cells and neutrophils.

Langerhans' cells usually have char¬acteristic nuclei The nuclei are often elongated, lobulated with prominent grooves and folds.

The Cytoplasm is acidophilic and abundant.

Most Langerhans' cells are mononuclear but occasionally they hove several nuclei On electron microscopic examination the Langerhans'cell shows specific intracytoplasmic organelles (Birbeck's granules).

For years this method has been used for identifying the Langerhans'celt Today immunohistochemistry stain is a reliable method for definite diagnosis.

According to Histiocyte Society even a typical clinical and light microscopic picture must be con¬firmed by a positive Slot) or CD,a immunohisto-chemistry stains.