Advanced maternal grandmother age and maternal age as risk factors for down syndrome in a group of Jordanian families
Joint Authors
Source
Journal of the Royal Medical Services
Issue
Vol. 17, Issue 3 (30 Sep. 2010), pp.51-56, 6 p.
Publisher
The Royal Medical Services Jordan Armed Forces
Publication Date
2010-09-30
Country of Publication
Jordan
No. of Pages
6
Main Subjects
Topics
Abstract EN
Objectives : To study whether advanced maternal age and maternal grandmother age are associated with increased risk of Down syndrome siblings in a group of Jordanian families.
Methods : This study was conducted on 127 confirmed Down syndrome cases with the age range of 18 weeks gestation to 15 years old, which were referred between the period of 2005-2008 for cytogenetic analysis at the Cytogentics section, Princess Iman Research and Laboratory Sciences Center/King Hussein Medical Center.
Maternal and grandmaternal mother ages were obtained directly from the study group when the samples were collected from siblings.
The maternal age ranged between 19-45 years while the maternal grandmother’s age ranged between 15-49 years.
One hundred healthy families were randomly recruited from the hospital staff as a control group.
Logistic regression was used for statistical analysis.
Results : One hundred seventeen down syndrome cases had free trisomy 21, 7 with translocation, 2 mosaic and one with double aneuploidy (47, XXY, +21).
Fifteen cases were diagnosed prenatally while 112 were diagnosed postnatally.
The effect of maternal age and maternal grandmother age were found to be significant using logistic regression statistics (P = 0.001 ; OR = 2.816 ; 95% CI, 1.48-5.33) for the mother’s age and (P = 0.001 ; OR = 2.902 ; 95%CI, 1.521-5.53) for the grandmother’s age.
Conclusion : Advanced maternal and maternal grandmother ages are risk factors for Down syndrome.
More studies and investigations are needed for better understanding of the biological factors responsible for the proper meiotic segregation of germ cells during the fetal development of the embryo in advanced maternal and grandmother’s age.
American Psychological Association (APA)
Nazmi, Kamal R.& Id, Suhayr S.. 2010. Advanced maternal grandmother age and maternal age as risk factors for down syndrome in a group of Jordanian families. Journal of the Royal Medical Services،Vol. 17, no. 3, pp.51-56.
https://search.emarefa.net/detail/BIM-179382
Modern Language Association (MLA)
Nazmi, Kamal R.& Id, Suhayr S.. Advanced maternal grandmother age and maternal age as risk factors for down syndrome in a group of Jordanian families. Journal of the Royal Medical Services Vol. 17, no. 3 (Sep. 2010), pp.51-56.
https://search.emarefa.net/detail/BIM-179382
American Medical Association (AMA)
Nazmi, Kamal R.& Id, Suhayr S.. Advanced maternal grandmother age and maternal age as risk factors for down syndrome in a group of Jordanian families. Journal of the Royal Medical Services. 2010. Vol. 17, no. 3, pp.51-56.
https://search.emarefa.net/detail/BIM-179382
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 56
Record ID
BIM-179382