Heterocyles XV . : one-pot synthesis of indenylpyrimidine-2-ones

Abstract EN

Condensation of 1- indanone , aryl aldehydes (Ia-K) and urea revealed the formation of the corresponding dihydropyrimidinones (IIa - K).

These were acetylated and brominated to give compounds (IID and (IV) respectively Dehydrogenation of (II) gave the corresponding pyrimidinones (V) The Structures of the products (II - V)were substantiated by chemical and spectral methods .

In a previous Work , 1- indanone was reacted with guanidine to produce 2- amino - indenylpyrimidines (1) On the other hand, indenylpyrimidine - 2 - ones were previously prepared through a multi - step synthesis (2,3) .

The present investigation describes a one - pot synthesis of some new dihydropyrimidinones (IIa - K) .

Thus 1- indanone and urea were condensed with aryl aldehydes (Ia - K) to produce the corresponding 4 - atyl - 3,4 - dihydro - 5 tHl - indenyl (1,2 -e) pyrimidin - 2 (IH) ones (IIa - K) (2,3) .

The structure of these products was substantiated by chemical and spectral