Hepatitis C virus infection and gene expression of hepatocellular carcinoma in Egyptian patients
Joint Authors
Ali, Ula Sayyid M.
Mansur, Muhammad Tariq M.
Basyuni, Hala T.
Abd al-Maqsud, Sahar M.
al-Awadi, Rehab Rifate
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 10, Issue 2 (30 Nov. 2009), pp.218-226, 9 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2009-11-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Topics
Abstract EN
Introduction: Gene expression profiling of hepatocellular carcinoma (HCC) is promising for refining the diagnosis and prognosis as well as identifying potential therapeutic targets.
Aim of the Study: Our study aimed to study the gene expression in 40 HCC patients infected with hepatitis C virus (HCV) using RT-PCR technique on surgical liver sample.
Gene expression changes in HCV-positive group were compared with gene expression in HCV-negative group.
Four genes were included in this study, AFP gene, CD10 gene, HGF gene and GRB2 gene.
The expression of the four genes were slightly higher in HCV positive group than in HCV negative group, however, the difference between the two groups was non-significant.
HGF gene was expressed in only 20% of HCC patients and GRB2 gene was expressed in 95% of HCC patients.
AFP gene and CD10 gene were expressed in all patients.
Conclusion: AFP gene, CD10 gene and GRB2 gene play an important role as diagnostic markers of HCC.
American Psychological Association (APA)
Ali, Ula Sayyid M.& Mansur, Muhammad Tariq M.& Basyuni, Hala T.& Abd al-Maqsud, Sahar M.& al-Awadi, Rehab Rifate. 2009. Hepatitis C virus infection and gene expression of hepatocellular carcinoma in Egyptian patients. The Egyptian Journal of Medical Human Genetics،Vol. 10, no. 2, pp.218-226.
https://search.emarefa.net/detail/BIM-203773
Modern Language Association (MLA)
Ali, Ula Sayyid M.…[et al.]. Hepatitis C virus infection and gene expression of hepatocellular carcinoma in Egyptian patients. The Egyptian Journal of Medical Human Genetics Vol. 10, no. 2 (Nov. 2009), pp.218-226.
https://search.emarefa.net/detail/BIM-203773
American Medical Association (AMA)
Ali, Ula Sayyid M.& Mansur, Muhammad Tariq M.& Basyuni, Hala T.& Abd al-Maqsud, Sahar M.& al-Awadi, Rehab Rifate. Hepatitis C virus infection and gene expression of hepatocellular carcinoma in Egyptian patients. The Egyptian Journal of Medical Human Genetics. 2009. Vol. 10, no. 2, pp.218-226.
https://search.emarefa.net/detail/BIM-203773
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 224-226
Record ID
BIM-203773