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Serotonin receptors : a review of their function and possible significance in psychiatric disease
Other Title(s)
مستقبلات السريتونين : مراجعة لوظائف و أهميتهم الممكنة في المرض النفسي
Author
Source
The Arab Journal of Psychiatry
Issue
Vol. 7, Issue 1 (31 May. 1996), pp.1-26, 26 p.
Publisher
The Arab Federation of Psychiatrists
Publication Date
1996-05-31
Country of Publication
Jordan
No. of Pages
26
Main Subjects
Abstract EN
Thirty-three years ago Gaddum and Picarelli classified the serotonin receptors in the guinea pig ileum into D and M types based on the activity of dibenzyline (D) and morphine (M) to block contractions of intestinal smooth muscle caused by serotonin.
The subsequent location of specific ligand binding sites for serotonin in the brain has led to the identification of ten serotonin receptor sub-types in art brain.
While there is some controversy over the functional importance of many of these receptor sub-types, there is evidence that they fall into two major groups according to the nature of their coupling to secondary messengers or ion channels.
Thus the 5HT1 and 5HT2 receptors appear to occupy the G protein receptor subfamily which may be coupled either to adenylate cyclase (most 5HT1 sub-types) or phosphatidyl inositol (5HT2 sub-types).
The central M receptors (now termed 5HT3) appear to occupy a ligand gated ion channel super family.
The cloning of these receptor sub-types has been of importance in enabling them to be classified as specific protein molecules encoded by specific genes.
The problem now arises with regard to the linking of the changes in the cellular activity of the various receptor sub-types with the plethora of behavioural changes that arise as a consequence of the actions of serotonin in the brain.
The present review summarizes the evidence implicating the role of specific serotonin receptor sub-types in thermoregulation, modulation of cardiovascular function, eating disorders, sleep, sexual activity, anxiety states, aggression, schizophrenia and depression.
A summary of the relationship between these receptor sub-types and their possible involvement in the etiology of these diseases is shown in Table 2.
American Psychological Association (APA)
Leonard, Brian E.. 1996. Serotonin receptors : a review of their function and possible significance in psychiatric disease. The Arab Journal of Psychiatry،Vol. 7, no. 1, pp.1-26.
https://search.emarefa.net/detail/BIM-207182
Modern Language Association (MLA)
Leonard, Brian E.. Serotonin receptors : a review of their function and possible significance in psychiatric disease. The Arab Journal of Psychiatry Vol. 7, no. 1 (May. 1996), pp.1-26.
https://search.emarefa.net/detail/BIM-207182
American Medical Association (AMA)
Leonard, Brian E.. Serotonin receptors : a review of their function and possible significance in psychiatric disease. The Arab Journal of Psychiatry. 1996. Vol. 7, no. 1, pp.1-26.
https://search.emarefa.net/detail/BIM-207182
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references: p. 17-26
Record ID
BIM-207182