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Thrihexyphenidyl abuse : a controlled investigation between users and misuses
Other Title(s)
سوء استعمال ترايهكسيفينيديل : دراسة ضابطة
Joint Authors
Abd al-Qadir, Muzamil Hasan
al-Umari, Ala al-Din
al-Harka, Isam
Qurashi, Nasim Akhtar
Source
The Arab Journal of Psychiatry
Issue
Vol. 7, Issue 2 (30 Nov. 1996), pp.139-151, 13 p.
Publisher
The Arab Federation of Psychiatrists
Publication Date
1996-11-30
Country of Publication
Jordan
No. of Pages
13
Main Subjects
Abstract EN
Objective: This controlled study aim to identify the socioclinical factors predisposing psychiatric patients to misuse trihexyphenidyl and to document the extrapyramidal features in both trihexyphenidyl (Artane) abusers and non-abusers.
Method: Thirty patients [n=30] with mainly two major functional psychoses and abusing trihexyphenidyl were compared with ninety Artane non-abusers patients [n=90| who were matched both for the diagnosis and treatment.
Besides detailed clinical interview, each patient was assessed by using DSM-IIIR criteria, Brief Psychiatric Rating Scale, Simpson and Angus Scale, and Abnormal Involuntary Movement Scale.
Results: Comparatively, trihexyphenidyl abusers were significantly characterized by being ever-married, unemployed, smoking and having past and concurrent history of multiple drug abuse, and genetic loading of mental disorders.
Both groups of patients were prescribed antipsychotic drugs and trihexyphenidyl on long-term basis.
Besides other socioclinical parameters, premorbid personalities, stressful life events and extrapyramidal symptoms including tardive dyskinesia did not differentiate the two groups.
Artane abusers, when compared with non-abusers, were significantly less characterized by negative psychopathology.
However, other psychopathological domains including depressive and positive symptoms did not differentiate between abusers and non-abusers.
Conclusions: The patients having these socioclinical profiles tend to develop trihexyphenidyl abuse.
Psychiatrists should not prescribe trihexyphenidyl indiscriminately and for a long time to such patients, who indeed require long-term antipsychotic maintenance medications.
American Psychological Association (APA)
Qurashi, Nasim Akhtar& al-Umari, Ala al-Din& Abd al-Qadir, Muzamil Hasan& al-Harka, Isam. 1996. Thrihexyphenidyl abuse : a controlled investigation between users and misuses. The Arab Journal of Psychiatry،Vol. 7, no. 2, pp.139-151.
https://search.emarefa.net/detail/BIM-207846
Modern Language Association (MLA)
Qurashi, Nasim Akhtar…[et al.]. Thrihexyphenidyl abuse : a controlled investigation between users and misuses. The Arab Journal of Psychiatry Vol. 7, no. 2 (November 1996), pp.139-151.
https://search.emarefa.net/detail/BIM-207846
American Medical Association (AMA)
Qurashi, Nasim Akhtar& al-Umari, Ala al-Din& Abd al-Qadir, Muzamil Hasan& al-Harka, Isam. Thrihexyphenidyl abuse : a controlled investigation between users and misuses. The Arab Journal of Psychiatry. 1996. Vol. 7, no. 2, pp.139-151.
https://search.emarefa.net/detail/BIM-207846
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 148-151
Record ID
BIM-207846