Hepatitis C associated chronic liver disease in renal transplant recipients
Joint Authors
Abd Allah, Abd Allah H.
al-Sulayman, Muhammad Hasan
Musa, Dujana H.
Rasul, Zalmai
Abd al-Rahman, Muhammad
al-Khidr, Abd Allah
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 6, Issue 2 (30 Apr. 1995), pp.179-182, 4 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
1995-04-30
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
Abstract EN
Infection with Hepatitis C Virus (HCV) is emerging as a major cause of morbidity and mortality in renal transplant recipients.
We studied three hundred and forty stable renal transplant recipients on follow-up in our transplant clinic.
Anti-HCV, tested by second generation ELISA, was positive in 185 patients (54%) of whom 52 (28%) had evidence of chronic liver disease.
Six of the study patients were positive for anti-HCV and hepatitis B surface antigen.
Twenty-three patients consented to undergo liver biopsy of whom eight had normal histology or fatty changes.
Five patients had chronic non-specific hepatitis; four each had chronic lobular and chronic active hepatitis (CAH) and two had CAH with cirrhosis.
All 15 patients with significant abnormalities on liver histology had elevated serum transaminase levels.
Repeat liver biopsies were performed in seven patients after a mean period of 23.8 months following the first biopsy which showed worsening of the disease in four while three retained the same pattern.
These results suggest that the prevalence of anti-HCV in our renal transplant recipients is high and that these patients have a high prevalence of chronic liver disease associated with major changes on liver histology.
It is therefore recommended that caution is exercised while considering transplantation in patients who are anti-HCV positive
American Psychological Association (APA)
Abd Allah, Abd Allah H.& al-Sulayman, Muhammad Hasan& Musa, Dujana H.& Rasul, Zalmai& Abd al-Rahman, Muhammad& al-Khidr, Abd Allah. 1995. Hepatitis C associated chronic liver disease in renal transplant recipients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 6, no. 2, pp.179-182.
https://search.emarefa.net/detail/BIM-209183
Modern Language Association (MLA)
Abd Allah, Abd Allah H.…[et al.]. Hepatitis C associated chronic liver disease in renal transplant recipients. Saudi Journal of Kidney Diseases and Transplantation Vol. 6, no. 2 (December 1995), pp.179-182.
https://search.emarefa.net/detail/BIM-209183
American Medical Association (AMA)
Abd Allah, Abd Allah H.& al-Sulayman, Muhammad Hasan& Musa, Dujana H.& Rasul, Zalmai& Abd al-Rahman, Muhammad& al-Khidr, Abd Allah. Hepatitis C associated chronic liver disease in renal transplant recipients. Saudi Journal of Kidney Diseases and Transplantation. 1995. Vol. 6, no. 2, pp.179-182.
https://search.emarefa.net/detail/BIM-209183
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 181-182
Record ID
BIM-209183