New concepts to individualize calcineurin inhibitor therapy in renal allograft recipients
Joint Authors
Sommerer, Claudia
Giese, Thomas
Meuer, Stefan
Zeier, Martin
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 21, Issue 6 (31 Dec. 2010), pp.1030-1037, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2010-12-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Topics
Abstract EN
A maximum of efficacy with a minimum of toxicity is the ultimate goal of immunosuppressive therapy.
Calcineurin inhibitors are widely used as immunosuppressive drugs, and there is still a discussion about the optimal blood levels of cyclosporine A (CsA) and tacrolimus (Tac), balancing safety and efficacy.
Monitoring of calcineurin inhibitor therapy is usually performed by blood trough levels, pharmacokinetics such as measurement of two-hour peak levels, or by various areas under the curve assessments (AUC, 4 to 12 hours).
All these mentioned pharmacokinetic measurements cannot predict the individual biological effects of the immunosuppressive drug.
Several approaches have been undertaken to measure immunosuppression by calcineurin inhibitors.
In this manuscript, general and specific immune monitoring strategies of calcineurin inhibitors and their clinical benefits are discussed.
American Psychological Association (APA)
Sommerer, Claudia& Giese, Thomas& Meuer, Stefan& Zeier, Martin. 2010. New concepts to individualize calcineurin inhibitor therapy in renal allograft recipients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 21, no. 6, pp.1030-1037.
https://search.emarefa.net/detail/BIM-215641
Modern Language Association (MLA)
Sommerer, Claudia…[et al.]. New concepts to individualize calcineurin inhibitor therapy in renal allograft recipients. Saudi Journal of Kidney Diseases and Transplantation Vol. 21, no. 6 (Dec. 2010), pp.1030-1037.
https://search.emarefa.net/detail/BIM-215641
American Medical Association (AMA)
Sommerer, Claudia& Giese, Thomas& Meuer, Stefan& Zeier, Martin. New concepts to individualize calcineurin inhibitor therapy in renal allograft recipients. Saudi Journal of Kidney Diseases and Transplantation. 2010. Vol. 21, no. 6, pp.1030-1037.
https://search.emarefa.net/detail/BIM-215641
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1035-1037
Record ID
BIM-215641