Serum level of heart-type fatty acid-binding protein in patients with chronic renal failure

Abstract EN

Objectives : Heart-type fatty acid binding-protein (H-FABP) has been reported to be a potential novel biochemical marker for the early diagnosis of acute myocardial infarction (AMI).

The effect of kidney diseases on the renal handling of H-FABP has not yet been fully evaluated.

The aim of this study was to compare the effect of renal failure on the level of H-FABP and cardiac troponin (cTnT) concentrations.

Methods : The study population was a small group of 16 patients with renal failure (6 females, 10 males aged 30-70 years) on routine regular haemodialysis or peritoneal dialysis.

Results : The mean ± SD of serum urea and creatinine concentration in this group of patients was 19 ± 9.6 mmol / L and 531.3 ± 231.2 mmol / L respectively.

H-FABP was increased in all 16 patients (81 ± 53.3μg / L).

The cTnT was increased ≥ 0.1μg / L in 8 patients (50 %), ≥ 0.2μg / L in 5 patients (31.3 %), and ≥ 0.3μg / L in 1 patient (6 %).

Conclusion : The diagnostic efficiency of H-FABP and cTnT for the diagnosis of AMI in the presence of renal failure may be limited and such patients may have high levels even in the absence of AMI.