Hyperhemocysteinemia and cardiovascular risks in hemodialysis patients
Joint Authors
Ostovan, Muhammad Ali
Sohrabi, Zahra
Atabati, Ilham
Roozbeh, Jamshid
Saghib, Muhammad Mahdi
Jalali, Ghanbar Ali Raiss
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 21, Issue 5 (31 Oct. 2010), pp.863-866, 4 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2010-10-31
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
- Patients
- Cardiovascular system
- Kidneys
- Diseases
- Amino acids
- Chronic diseases
- Hemodialysis
- Blood
- Complications(Medicine)
- Kidney failure
Abstract EN
The risk of premature and progressive occlusive vascular disease is high in chronic uremic patients, and it accounts for more than 40% of the mortality in dialysis patients.
End stage renal failure (ESRF) patients exhibit elevated plasma homocystein levels, about four fold as much as those in the controls, and it is now considered as a causative factor for increased risk of cardiovascular death among these patients.
The aim of this study was to evaluate the relationship of total plasma homocysteine level and echocardiographic abnormalities as a surrogate of cardiac disease outcome in hemodialysis patients.
123 adult patients on maintenance hemodialysis and having echocardiography done during January till November 2006 were enrolled in this crosssectional study.
Plasma homocysteine level was directly related to the presence of aortic regurgitation r= 0.27 P= 0.009.
There were negative correlations between ejection fraction (EF), left ventricular systolic dimension (LV.S) (r= - 0.71, P= 0.0001), left ventricular diastolic dimension (LV.D) (r= -0.23 p= 0.01) and age (r= - 0.021 P= 0.02).
In conclusion we did not find the paradoxical reverse epidemiology in our patients and plasma total homocysteine level was in direct correlation with cardiac risk factors such as left ventricular mass index and aortic regurgitation.
American Psychological Association (APA)
Saghib, Muhammad Mahdi& Ostovan, Muhammad Ali& Sohrabi, Zahra& Atabati, Ilham& Jalali, Ghanbar Ali Raiss& Roozbeh, Jamshid. 2010. Hyperhemocysteinemia and cardiovascular risks in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 21, no. 5, pp.863-866.
https://search.emarefa.net/detail/BIM-216064
Modern Language Association (MLA)
Saghib, Muhammad Mahdi…[et al.]. Hyperhemocysteinemia and cardiovascular risks in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation Vol. 21, no. 5 (Oct. 2010), pp.863-866.
https://search.emarefa.net/detail/BIM-216064
American Medical Association (AMA)
Saghib, Muhammad Mahdi& Ostovan, Muhammad Ali& Sohrabi, Zahra& Atabati, Ilham& Jalali, Ghanbar Ali Raiss& Roozbeh, Jamshid. Hyperhemocysteinemia and cardiovascular risks in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation. 2010. Vol. 21, no. 5, pp.863-866.
https://search.emarefa.net/detail/BIM-216064
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 866
Record ID
BIM-216064