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Surrogate markers of subtle renal injury in patients with visceral leishmaniasis
Joint Authors
al-Nujumi, N. A. A.
Musa, Ahmad Madwi
al-Faki, M. E. E.
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Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 21, Issue 5 (31 Oct. 2010), pp.872-875, 4 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2010-10-31
Country of Publication
Saudi Arabia
No. of Pages
4
Main Subjects
Topics
Abstract EN
Sudanese Visceral Leishmaniasis (VL) is a disease of children that is characterized by fever, hepatosplenomegaly, lymphadenopathy, pancytopenia, and renal injury.
Microalbuminuria (MA) and urinary retinol binding protein (urRBP) are useful markers for glomerular and tubular dysfunctions, respectively.
We report the prevalence of subtle renal injury in 88 parasitologically confirmed VL patients in a cross-sectional and hospital-based study.
Blood and urine were collected before treatment for hematological, biochemical profiles in addition to MA and urRBP measurement using competitive solid phase, sandwich enzyme-linked immune sorbent assay (ELISA), and immunoturbidometry.
All the patients had normal serum urea and creatinine levels and no detectable urRBP.
However, 40% of the patients had MA detected by ELISA, and 42% were reactive with turbidometry.
The sensitivity, specificity, positive and negative predictive values for MA turbidometric technique were calculated as 100%; 96%; 95% and 100%, respectively.
In conclusion; subtle renal injury in VL is mainly glomerular.
Turbidometry for MA measurement is a simple, inexpensive, sensitive, and specific technique with high predictive values.
American Psychological Association (APA)
al-Nujumi, N. A. A.& Musa, Ahmad Madwi& Yunus, B. M.& al-Faki, M. E. E.& al-Hasan, Ahmad Muhammad. 2010. Surrogate markers of subtle renal injury in patients with visceral leishmaniasis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 21, no. 5, pp.872-875.
https://search.emarefa.net/detail/BIM-216380
Modern Language Association (MLA)
Musa, Ahmad Madwi…[et al.]. Surrogate markers of subtle renal injury in patients with visceral leishmaniasis. Saudi Journal of Kidney Diseases and Transplantation Vol. 21, no. 5 (Oct. 2010), pp.872-875.
https://search.emarefa.net/detail/BIM-216380
American Medical Association (AMA)
al-Nujumi, N. A. A.& Musa, Ahmad Madwi& Yunus, B. M.& al-Faki, M. E. E.& al-Hasan, Ahmad Muhammad. Surrogate markers of subtle renal injury in patients with visceral leishmaniasis. Saudi Journal of Kidney Diseases and Transplantation. 2010. Vol. 21, no. 5, pp.872-875.
https://search.emarefa.net/detail/BIM-216380
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 874-875
Record ID
BIM-216380