The influence of body mass index on glycosylated hemoglobin and lipid profile in diabetic patients

Abstract EN

Background : Obesity is a powerfull independent contributer to the onset of diabetes mellitus and risk is related to the degree of obesity. Objective : The study was desingend to investigate the influence of the body mass index on the levels of glycosylated hemoglobin and the parameters of serum lipid profile in patients with IDDM and NIDDM. Methods : A total of 100 diabetic patients 40 IDDM patients (20 males and 20 females) and 60 NIDDM patients (30 males and 30 females) were randomly selected from AL-Hakeem diabetic center in AL-Sadder Hospital in Najaf in parallel with 50 healthy subjects as control group.

5 ml of venous blood were obtained from each healthy and diabetic subjects, 1 ml of blood put in EDTA tube for HbA1c determination using ion exchange HPLC instrument.

Lipid profile parameters were evaluated using the Spainreact kits with standared methods. Results : The results revealed that the mean of body mass index was 27 ± 0.5 kg / m2 for males and 25 ± 0.5 for females 37.5 % of the male patients were obese, while the obesity in females were found 72 %.

As well as the levels of serum total cholesterol, triglycerides are higher in females as compared with their males counterpart.

Significant correlations were present between the body mass index and glycosylated hemoglobin (r = 0.58, p < 0.05), serum total cholesterol (r = 0.5, p < 0.05) in diabetic male patients, however in diabetic female patients showed a highly significant correlation between the body mass index and glycosylated hemoglobin (r = 0.7, p< 0.05) and serum total cholesterol (r = 0.6, p < 0.05), serum triglycerides (r = 0.57, p < 0.05), LDL-cholesterol (r = 0.51, p< 0.05), VLDL-triglycerides (r = 0.52, p< 0.05) in type 2 diabetic male patients.

While in type 2 diabetic female patients was found serum triglycerides (r = 0.56, p< 0.05 ), LDL-cholesterol (r = 0.59, p< 0.05), VLDL-triglycerides (r = 0.85, p< 0.005). Conclusion : the highly positive correlations between the BMI and HbA1c, TC, S.Tg, LDLcholesterol, VLDL- triglycerides suggest that the relationship between diabetes and lipid metabolism.