Evaluation of the psychopharmacological effects of loratadine with concomitant adminstration of erythromycin

Abstract EN

In this study, the effect of a single oral dose (10 mg) of a 2nd generation antihistaminic Agent – loratadine - administered alone or with a metabolic inhibitor – erythromycin - on psychomotor performance was investigated on 6 healthy volunteers. Recording of movement reaction time and assessment of subjective feeling of sedation was done before medication and hourly afterward for 3 hours. The results were analyzed statically by using “student’s t test” which showed that loratadine erythromycin combination induced a statically significant impairment of psychomotor performance demonstrated by prolongation of finger tip reaction time.