Impact of cytotoxin-associated gene A of Helicobacter pylori strains on microalbuminuria in type 2 diabetes
Joint Authors
Ibrahim, Amani
Ghunaymi, Tariq A.
Abd Al-Azim, Shayma
Abd Al-Azim, Marwah
Ramadan, Ayman
Zahir, Tariq I.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 21, Issue 4 (30 Aug. 2010), pp.694-700, 7 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2010-08-30
Country of Publication
Saudi Arabia
No. of Pages
7
Main Subjects
Topics
Abstract EN
Cytotoxin-associated gene A (CagA) positive strains of H.
pylori have a significant correlation with gastritis and peptic ulcer, and may induce persistent systemic inflammatory response, increase vascular damage, and compromise glycemic control in diabetic patients.
To evaluate correlation between infection by cagA positive strains of H.
pylori and occurrence of microalbuminuria and glycemic control in type 2 diabetic patients, we prospectively studied 98 dyspeptic type 2 diabetic patients as a study group and 102 dyspeptic non-diabetic subjects as a control group.
Gastric biopsy specimens obtained with endoscopy were cultured to isolate H.
pylori.
All the isolated H.
pylori strains from cultures were used for detection of cagA gene by polymerase chain reaction.
There was no significant difference between study and control groups regarding infection with cagA positive strains of H.
pylori ( P= 0.145).
Furthermore, there was no significant differences between both groups concerning the incidence of microalbuminuria ( P= 0.145).
On the other hand, there was an extremely statistically significant difference in the incidence of microalbuminuria and glycemic control in the diabetic patients between those infected with cagA positive strains of H.
pylori and cag A negative starins (P= 0.000).
We conclude that infection with cagA positive strains of H.
pylori are strongly associated with the increased incidence of microalbuminuria and poor glycemic control in type 2 diabetic patients.
American Psychological Association (APA)
Ibrahim, Amani& Zahir, Tariq I.& Ghunaymi, Tariq A.& Abd Al-Azim, Shayma& Abd Al-Azim, Marwah& Ramadan, Ayman. 2010. Impact of cytotoxin-associated gene A of Helicobacter pylori strains on microalbuminuria in type 2 diabetes. Saudi Journal of Kidney Diseases and Transplantation،Vol. 21, no. 4, pp.694-700.
https://search.emarefa.net/detail/BIM-218746
Modern Language Association (MLA)
Ibrahim, Amani…[et al.]. Impact of cytotoxin-associated gene A of Helicobacter pylori strains on microalbuminuria in type 2 diabetes. Saudi Journal of Kidney Diseases and Transplantation Vol. 21, no. 4 (Sep. 2010), pp.694-700.
https://search.emarefa.net/detail/BIM-218746
American Medical Association (AMA)
Ibrahim, Amani& Zahir, Tariq I.& Ghunaymi, Tariq A.& Abd Al-Azim, Shayma& Abd Al-Azim, Marwah& Ramadan, Ayman. Impact of cytotoxin-associated gene A of Helicobacter pylori strains on microalbuminuria in type 2 diabetes. Saudi Journal of Kidney Diseases and Transplantation. 2010. Vol. 21, no. 4, pp.694-700.
https://search.emarefa.net/detail/BIM-218746
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 699-700
Record ID
BIM-218746