Histological and physiological alterations resulted from aqueous extract of grewia tenax administration in swiss albino mice

Abstract EN

Recently in Libya and many other countries, Grewia tenax was found to be used traditionally for treatment a variety of diseases as anemia.

Thus, it is possible to develop a drug to treat different types of anemia.

The objective of this study was to investigate the effect of repeated high dose of aqueous extract of Grewia tenax (leaves & fruits ) on some hematological parameters (HB, PCV, RBCs, WBCs & Platelets counts) and some biochemical parameters including serum activities of ALT or SGPT, AST or SGOT, creatinine and urea for testing liver and kidney functions.

As well as, the present work aimed to study the histological effects of aqueous extract of Grewia tenax administration on liver and kidney tissue.

Data were statistically analyzed using student-t test.

Selected organs (liver& kidney) from both control and treated animals were examined microscopically for histopathological changes.

The results showed that, administration of aqueous extract of Grewia tenax induced significant (p < 0.05) increase in Hb concentration, PCV % and RBCs count.

On the other hand, a significant (p < 0.05) decrease in WBCs count was recorded as compared to control group.

However, no significant change in platelets counts.

Biochemical parameters revealed significant increase in treated group when compared to control.

Microscopic examination revealed signs of pathological alterations which were more pronounced in the liver.

This study indicates the possible utility of aqueous extract of Grewia in treatment of some blood diseases characterized by decreasing hemoglobin concentration and RBCs count.

However, these data were not considered sufficient to assess the safety of this natural plant.