Evaluation of parenteral treatment of colibacillosis in pre-weaning

Abstract EN

Thirty, 1-2 month old pre-weaning Egyptian buffalo calves in a private farm at Sharkia Governorate were divided into naturally diarrheic calves and non diarrheic calves were subdivided into two equal groups.

The first group was treated intramuscular (1 / M) with amoxicillin suspension (clamoxyl L.

A ®) at a dose level of 1ml / 15Kg B.

wt .

and the second group was treated 1 / M with amoxicillin potentiated clavulinic acid (Synulox ®) at dose of 1ml / 20 kg for 3 successive days.

Rectal swabs were aseptically collected from diarrheic and healthy calves.

Bacteriological examination of isolates revealed that E.

coli strains were the main causative agent of diarrhea in diseased calves.

Susceptibility of isolated strains to different antimicrobials was conducted and showed that amoxicillin potentiated with clavulinic acid was highly effective.

Blood samples from studied calves before and after treatment were collected for biochemical and hematological studies.

In diseased calves, a significant decrease in serum total protein with its albumin and globulin in addition to immunoglobulin, hemoglobin decreases also were recorded.

While leukocytosis and significant increases in platelets were noticed.

A non significant decrease in sodium with a significant decrease in potassium were recorded in diseased calves.

Parenteral treatment of diarrheic calves with amoxicillin potentiated with clavulinic acid was more effective than amoxicillin alone in reducing the clinical symptoms and improvement of general health conditions.