تأثير التجويع على انغراس الأجنة و منتوج الحمل في الفئران المختبرية

Abstract EN

Adult inbred SWR/J mice were used to investigate the effect of various durations (D0 → D14) of female starvation, a three-day each, on implantation and pregnancy outcome.

The results of this study clearly showed that female starvation during the periods D0 → D14 had blocked this process and resulted in a significant (p<0.05) increase in the percentages of female mortality, and a significant (p<0.05) decrease in the means of female body weight gain as compared to the control group.

Moreover, a significant (p<0.05) decrease in the means of female body weight gain had also been observed during the periods D6 → D14 of female starvation.

However, female starvation had significantly (p<0.05) increased the percentages of female mortality during the periods D9 → D14, and significantly (p<0.05) increased the percentages of abortion during the periods D12 → D14 only.

A highly significant (p<0.01) reduction in the mean numbers of live fetuses, means of live fetal body weights and means of placental weights, and a highly significant (p<0.01) increase in the percentages of dead and resorped emloryos and fetuses were observed during the periods D6 → D14 of female starvation.

Furthermore, female starvation during the periods D10 → D14 highly significantly (p<0.01) decreased the mean numbers of live pups and the means of their body weights.

Moreover, such starvation also resulted in a highly significant (p<0.01) increase in the percentages of dead pups at parturition and at the end of the sixth week of their lives.

However, no live pups had been obtained from the dams starved during the period D6 → D9 and no malformations had been observed in the fetuses or the pups of the females starved during the periods D6 → D14.