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Effect of acute and subchromic administration of nutmeg seed's extract on mice behavioure, histological structure and biochemical functions
Other Title(s)
التأثيرات السامة الحادة و تحت المزمنة لمستخلص جوزة الطيب على الوظائف السلوكية و الكيموحيوية و التركيب النسيجي في الفئران
Joint Authors
al-Hazimi, Mansur Bin Atiyyah
al-Saqqaf, Ahmad Bin Ibrahim
al-Sayyid, Jamal Nasir Id
Bin Nasir, Yasir Sad Musa
Source
Saudi Journal of Biological Sciences
Issue
Vol. 11, Issue 2 (31 Dec. 2004), pp.177-188, 12 p.
Publisher
Publication Date
2004-12-31
Country of Publication
Saudi Arabia
No. of Pages
12
Main Subjects
Topics
Abstract EN
Whole or ground nutmeg, the dried seed of the evergreen nutmeg tree (Myristica fragrant Houtt), is readily and widely available.
It is commonly used as a spice for many and for many other medicinal purposes.
The present study aimed to investigating the effects of acute and sub chronic intraperitoneal administration of nutmeg extract on MFI-mice behavioral functions.
It also aimed at illustrating the effects on the histological structure and biochemical functions of the heart, the liver and the kidneys in MFI-mice.
An aqueous extract of nutmeg seeds was injected intra peritoneal to male- MFl mice as a single dose for the acute toxicity study and daily for 6 weeks for the sub chronic toxicity study.
Three dose levels equivalent to 20, 40 and 80 mg extract/kg the mice body weight were used.
The acute toxicity showed no statistically significant alteration in any of the behavioral parameters.
Regarding the sub chronic study, results of the three tested dose levels, indicated absence of any statistically significant effects on body weight of nutmeg treated mice.
Concerning behavioral parameters, results indicated absence of any statistically significant variation in the locomotor activity measures in the nutmeg-treated mice.
However, compared to the control, nutmeg-treated mice showed statistically significant alteration in the biochemical indicators of liver function including reduction of total protein and serum albumin and Significant elevation of se PT and SCOT.
Examination of the liver tissue confirmed a potential histopathological effects for nutmeg as evidenced by hydropiC and fatty degeneration in nutmeg treated mice.
These hepato-toxic effects of nutmeg were corrected structurally to some extent and not functionally by vitamin C administration.
Blood urea, an index of the kidney function exhibited statistically Significant elevation in nutmeg treated mice compared to the control.
Histological nutmeg induced no evident pathological effects on kidney.
Myocardial indices notably SCOT and LDH showed significant elevation in the nutmeg treated mice even after treatment with vitamin C.
in conclusion, aqueous extract of nutmeg seeds was not deleterious to the mice behavior at the tested doses.
Meanwhile, the extract was toxic to the liver, and carriers a potential toxicity to kidneys and cardiac muscle, of MFI-mice a the tested dose levels.
Vitamin C corrected the toxic effects of nutmeg extract on the liver functions and structure, however, it failed to improve the indices of myocardial toxicity and failed to restore the blood urea to normal levels.
Further investigations are required to evaluate the effects of the different components of the nutmeg essential oil separately and to test other antidotes for nutmeg toxic effects.
Clinical study among nutmeg users may be of great value.
American Psychological Association (APA)
al-Hazimi, Mansur Bin Atiyyah& al-Saqqaf, Ahmad Bin Ibrahim& al-Sayyid, Jamal Nasir Id& Bin Nasir, Yasir Sad Musa. 2004. Effect of acute and subchromic administration of nutmeg seed's extract on mice behavioure, histological structure and biochemical functions. Saudi Journal of Biological Sciences،Vol. 11, no. 2, pp.177-188.
https://search.emarefa.net/detail/BIM-240318
Modern Language Association (MLA)
al-Hazimi, Mansur Bin Atiyyah…[et al.]. Effect of acute and subchromic administration of nutmeg seed's extract on mice behavioure, histological structure and biochemical functions. Saudi Journal of Biological Sciences Vol. 11, no. 2 (Dec. 2004), pp.177-188.
https://search.emarefa.net/detail/BIM-240318
American Medical Association (AMA)
al-Hazimi, Mansur Bin Atiyyah& al-Saqqaf, Ahmad Bin Ibrahim& al-Sayyid, Jamal Nasir Id& Bin Nasir, Yasir Sad Musa. Effect of acute and subchromic administration of nutmeg seed's extract on mice behavioure, histological structure and biochemical functions. Saudi Journal of Biological Sciences. 2004. Vol. 11, no. 2, pp.177-188.
https://search.emarefa.net/detail/BIM-240318
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 186-187
Record ID
BIM-240318