Genotoxic effect of single and combined treatment with furadan sequestrene on the induction of micronuclei in bone marrow cells of and male mice

Abstract EN

The genotoxic effects of the carbonate insecticide, Faraday, and Sequestrate each applied singly or combined were studied using the micronucleus test in mice bone marrow cells.

Adult male mice were exposed to two doses, the LD50 and half of the LD50 of the two chemicals.

The LD50 of Faraday was O.5mg / kg body weight and the LD50 of sequestrate was 3 mg / kg body weight.

All doses induced a significant increase in the number of micro nucleated polychromatic erythrocytes (MNPCEs).

Moreover, the combined treatment with both chemicals led to stronger effects in the bone marrow of mice represented by higher number of cells with micronuclei compared to the single treatment of each of the two chemicals.

The observed results in this study indicated that a single and / or combined treatment of both the insecticide and Sequestrate were lactogenic, however, Faraday was more potent than Sequestrate.