Ultrastructural alterations induced by erythromycin on the kidney of mice

Abstract EN

This study has been carried out to detuning the effect of Erythromycin ethyl succinate on the ultrastructure of the kidney in mice after the administration with daily dose of 150 and 500 mglkg / b.w.

for 7 days in comparison to control animals.

Morphological changes in the renal corpuscles were observed assembled as glomerular hypertrophy, with meningeal proliferation and obvious congestion of the glomerular capillaries.

The proximal tubular lesions were also quite evident in the present experiment as indicated by their swollen, detachments from each other and inter-tubular invasion by inflammatory cells.

The ultra-structural changes in proximal tubular cells revealed by close packing and swelling of mitochondria, decrease of ribosomes, increase of lysosomes, reduction of heterochromatin, moreover euchromatin in the most nuclei, disorganization of apical microvilli of these cells.

Damage of the basal membrane inholdings and the dark large granules or bodies (inter-lamellar inclusions) that were observed in the cytoplasm of the proximal tubular cells treated with high dose of EM were also detected.

The distal tubular cells showed little morphological changes.