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Evaluation of subchronic exposure of the male rat's reproductive Evaluation of subchronic exposure of the male rat's reproductive
Joint Authors
Mahjub, Afaf Ahmad
al-Madani, Azza Hafiz
Source
Saudi Journal of Biological Sciences
Issue
Vol. 7, Issue 2 (31 Dec. 2000), pp.138-146, 9 p.
Publisher
Publication Date
2000-12-31
Country of Publication
Saudi Arabia
No. of Pages
9
Main Subjects
Topics
Abstract AR
نظرا للاستخدام الشائع لمركبات الكربامات في مجالات الزراعة و الصناعة و أغراض الصحة العامة مما أدى إلى زيادة معدلات التسمم الحاد.
فقد استهدف هذا البحث دراسة تأثير التعرض شبه المزمن لمركب ميثوميل على التغيرات الهرمونية و الهستوباثولوجية في خصية الجرذ.
و لقد نتج عن هذه الدراسة نقص هرمون التستوستيرون يعتد به إحصائيا مع وجود زيادة في مستوى هرموني منشط الجيم الأصفر و الهرمون الملوتن و كذلك هرمون اللبن.
كما أسفرت الدراسة الهستوباثولوجية عن ظهور درجات مختلفة من التغيرات التنكسية و التي تصل إلى تدمير كامل للخلايا.
و قد استمرت هذه التغيرات الهرمونية و الهستوباثولوجية إلى ما بعد التوقف عن التعرض لمبيد الميثوميل مما يدل على أن لمبيد الميثوميل تأثير متلف و مزمن على خصية الجرذ.
و هذا يوجب الحرص عند استخدام هذه المركبات طبقا لبرنامج محدد مع عناية خاصة لطريقة الاستعمال لتقليل نسبة الأخطار الناتجة.
Abstract EN
Carbonate insecticides are widely used in industry, agriculture and for public health purposes. Numerous incidents of acute carbonate poisoning have resulted from inhalation of sprays or contamination of crops or food.
This work was conducted to study the effect of sub chronic exposure to methomyl on hormonal and histopathologically changes in the rat testis.
The treated group received methomyl orally (17 mglkg in saline) daily for two months while, the control group received saline.
A significant decrease in the level of testosterone was observed in the intoxicated animals, while the levels of FSH, LH and prolactin were significantly increased.
Histopathologically studies of the intoxicated rat testis revealed variable degrees of degenerative changes in the seminiferous tubules up to total cellular destruction.
The hormonal changes and testicular damage continued for 30 days after withdrawal of the insecticide indicating a persistent effect.
From the above mentioned findings, it has been concluded that sub chronic exposure to methomyl insecticide has an obvious deleterious effects on rat testes.
Therefore, application of such insecticide should be limited to a designed programmer with special care in handling to limit or minimize its hazards.
American Psychological Association (APA)
Mahjub, Afaf Ahmad& al-Madani, Azza Hafiz. 2000. Evaluation of subchronic exposure of the male rat's reproductive Evaluation of subchronic exposure of the male rat's reproductive. Saudi Journal of Biological Sciences،Vol. 7, no. 2, pp.138-146.
https://search.emarefa.net/detail/BIM-240823
Modern Language Association (MLA)
Mahjub, Afaf Ahmad& al-Madani, Azza Hafiz. Evaluation of subchronic exposure of the male rat's reproductive Evaluation of subchronic exposure of the male rat's reproductive. Saudi Journal of Biological Sciences Vol. 7, no. 2 (Dec. 2000), pp.138-146.
https://search.emarefa.net/detail/BIM-240823
American Medical Association (AMA)
Mahjub, Afaf Ahmad& al-Madani, Azza Hafiz. Evaluation of subchronic exposure of the male rat's reproductive Evaluation of subchronic exposure of the male rat's reproductive. Saudi Journal of Biological Sciences. 2000. Vol. 7, no. 2, pp.138-146.
https://search.emarefa.net/detail/BIM-240823
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p 144-145
Record ID
BIM-240823