Maternal and fetal toxicity of mefenamic acid in swrlj mice

Abstract EN

Normal adult inbred SWRlJ mice were used to investigate the teratogenic, and other possible toxic et1ects of mefenamic acid (Ponstan) on both dams and their fetuses.

The dams were treated orally with various dose levels of the drug once each day from day 7 to day 12 of pregnancy.

Treatment at 25, 75 or 150 Ing/kg body weight of the drug had no toxic etlect on fetuses and their dams.

However, treatment at 300, 450 or 600 mg/kg body weight significantly (P

Moreover, treatment at 450 or 600 mg/kg significantly (P

On the other hand, the mean number of live fetuses significantly (P

Furthermore, the percentage of resorptions was also significantly (P

However, apart from abnormal hindlimbs ill only one fetus (300 mg/kg), no gross developmental defects were observed in any of the fetuses at any of the dose levels of mefenamic acid used.