Spectrophotometric determination of chlorpromazine hydrochloride in pharmaceutical preparations

Abstract EN

The present study includes analytical method for determination of the drug Chlorpromazine Hydrochloride (CPH) in some Pharmaceuticals using Molecular Absorption, in addition to investigating complexes obtained throughout.

The analytical data obtained throughout this study could be summaries as follows : The optimal experimental condition for the chelate formation : (pH = 1.8) ; concentration of Pd (II) (20 μg.

ml-1) ; reaction time (8 minutes) ; aqueous-to-organic phases (5 : 3) ; extraction time of complex (1.5 minute) ; Benzyl alcohol proved to be the best solvent for extraction of the complex CPH-Pd (II) without interference.

λmax = 459 nm metal-to-ligand (1 : 1) ; stability constant of complex CPH-Pd (II) (6.93 × 108 M-1). Analytical figures of merits for determination of CPH using the developed Procedure : Linear dynamic range (3-70) μg.

ml-1 ; Corrolation coffecient (r = 0.9993), Sandell Sensitivity (S = 0.0452μg.

cm-2) ; D.

L (0.13 μg.

ml-1) ; Erel.

% (0.18 %) ; RSD % (3.74 %), Recovery % (100.2 ± 0.42) %.

Direct and standard addition methods were applied to both standards and specimens of pharmaceutical.

Stability of complex was also investigated.

For optimization of experimental condition, the response surface method (RSM) was applied and data obtained were found similar.

This method has been applied to determination CPH in the well-known pharmaceutical Epichlor.