Synthesis and antibacterial activity of some hdrazides, substituted thiosemicarbazide, 1,3,4-oxadiazoles, thiadiazoles and 1,2,4- triazoles

Abstract EN

In the present work five ethyl esters (1-5) were treated with hydrazine hydrate in ethanol to give the corresponding acid hydracids (6-10).

The hydracids were converted to substituted thiosemicarbazides (11-14) by their reaction with phenyl isothiocyanate, while on heating at 150-200°C substituted 1, 2, 4- diazole was obtained (15).The thiosemicarbazides were converted to substituted 1, 2, 4- triazoles (16-19), 1, 3, 4- ox diazoles (20-22) and 1,3,4-thiadiazoles (23-26) by their reaction with sodium hydroxide, mercuric oxide in methanol and concentrated sulfuric acid respectively.

The synthesized compounds (7, 11, 15, 18, 20, 22, 24 and 26) were tested against Staph.

Aurous, bacillus.

Subtitles, protest mirabilis, E.

coli, K pneumonia and Pseudomonas aeroginosa, and the compounds (10, 16, 17, 19, 23 and 25) against E.

coli, pseudomonas aeroginosa, protest mirabilis and Staph.

Aurous.

The structures of the synthesized compounds were established by physical and spectral methods.