Measurement of creatinine clearance in non- insulin dependent diabetic patients

Abstract EN

This research was carried out in the period of February to June (2004), to measure cretonne clearance (CCl) in non-insulin dependent diabetes mellitus (NIDDM) patients.

The influence of age, sex, body mass index (BMI) and duration of the disease on the levels of (CCl) in NIDDM was also subsequently studied.

Blood samples were obtained from two groups : Group one (Non-insulin dependent diabetic group): Consist of 140 newly diagnosed or known non-insulin dependent diabetics.

Group two (Control group) : Consist of 60 apparently healthy individuals.

The mean (CCl) values were significantly lower in NIDDM than in controls (p < 0.001).

In Both groups : the mean levels of (CCl) in males significantly were higher than females (p < 0.05), also the mean levels of serum urea nitrogen (SUN) values were significantly higher in NIDDM than in controls (p < 0.001).This study conducted that the mean value (CCl) [decrease significantly with increasing the duration of the disease (p < 0.001).Versus the mean values of (SUN) increase significantly with increasing the duration of the disease (p < 0.001).