The relationship between testosterone hormone and lipid profile, proteins and some trace elements in the sera of patients with preeclampsia

Abstract EN

Preeclampsia is one of the most common diseases which occurs during the second and third trimester of pregnancy.

The incidence of this disease is 2-5% among pregnant women.

The aetiology is still in debate and many theories were introduced in this field by many investigators in different countries.

It is sometimes called disease of theories due to the contradictory issues concerning its causes and consequences.

In this study we tried to elucidate the relationship between testosterone and some biochemical constituents which vary during pregnancy (i.e , lipid profile, total protein, albumin and minerals (Ca & Mg).

This work was carried out on fifty five pregnant women referred to Babylon Hospital for Obstetric Paediatrics for the period from November 2007 to May 2008.

The serum samples obtained from those patients and control groups (55 healthy pregnant) were analyzed for lipids, protein and minerals addition to testosterone.

The study group was subdivided into four subgroups as follows : 1.Group I is comprised of 25 preeclamptic patients in the second trimester of pregnancy.

Group II is comprised of 30 preeclamptic patients in the third trimester of pregnancy.

3.

Group III includes 25 healthy pregnant women (2nd trimester) which served as control group.

4.Group IV represents 30 healthy pregnant subject in their third trimester of pregnancy The results revealed a significant increase in serum testosterone levels in Group I and Group II compared with Group III and IV (p<0.01).

These were insignificant decrease in hormone level in Group IV in comparison with GroupIII (p=0.36).

The results showed a significant increase in serum level of total cholesterol, TG, LDL, VLDL in Group I and Group II compared with those in Group III and Group IV,(p<0.001), (p<0.01) at respectively.

However, there was a concomitant decrease in serum HDL level in Group I and Group II when compared with Group III and Group IV.

The results showed also a significant decrease in the levels of total protein, albumin, Ca and Mg in preeclamptic women compared with normotensive pregnants (p<0.05).These changes were insignificant when the results of these component in Group IV were compared with Group III p>0.05).) There were significant correlation between serum testosterone levels and lipid profile, protein and minerals.

This gives a preliminary idea about the role of testosterone in such changes.

There were a positive correlation between testosterone and lipid profile except HDL-C which decrease at increase testosterone in G1,G2 and G3 (p<0.01) and there were positive correlation between cholesterol / albumin ratio and testosterone in G1,G2 and G3 (p<0.01) but a negative correlation in G4 (p<0.01).

There were inverse relationship between cholesterol and albumin (p<0.001).