The effect of recurrent use of clomiphene citrate in the treatment of infertility on the level of serum total protein, total cholesterol and triglyceride

Abstract EN

For the last forty years, the first line of treatment for anovulation in infertile women has been clomiphene citrate; the choice of clomiphene was appropriate because the drug was highly effective in inducing ovulation in selected patients with the advantage of being orally administered, relatively safe and inexpensive.

In contrast alternative treatment usually involved parenteral gonadotropins that were significantly more complicated and uncomfortable to administer.

However clomiphene was also found to have adverse effects, especially in the form of common antiestrogenic, endometrial and cervical mucous changes.

The aim of this study is to identify whether there is a relation between recurrent administration of clomiphene (as ovulation induction) and serum concentration of total protein, total cholesterol and triglyceride Thirty women were involved in this study, twenty with infertility and ten as control group.

The twenty infertile female patients undergo ovulation induction by clomiphene citrate as treatment to their condition.

The results show a significant difference in the serum level of total protein, total cholesterol and triglyceride between infertile patients (primary and secondary) and control group in the third month of clomiphene treatment The total protein was significantly higher in the control group than infertile patients; this is the same for total cholesterol while for triglyceride it was significantly higher in infertile patients than in the control group.