Serum malondialdehyde, total cholesterol, high density lipoprotein and vitamin c in welder workers

Abstract EN

Objective : we tested the hypothesis that the serum Malondialdehyde (MDA) total cholesterol (TC) high density lipoprotein cholesterol (HDL-C) and vitamin C concentration are affected in welder workers relative to non-welder subjects, and to clarify the relationship of MDA as marker of oxidative stress with these lipoproteins and vitamin C as antioxidant. Study design : A prospective case control study conducted at Basrah Province through a period of two months from the first of March till the end of April 2005.

Venous blood samples were collected for sixty welder workers, who were classified into 3 groups according to their age and to another 3 groups related to their duration of working, and another sixty non welders workers saved as a control group whose aged range (20-60) years. Serum was analyzed for concentrations of MDA, TC, HDL-C and vitamin C using standard methods.

Result : the results of the study showed significant increase in the concentrations of serum MDA, TC and HDL-C levels and significant decreases in the concentration of vitamin C (P<0.05) with advancing age in welders relative to non welder workers.

Further more, there were significant gradual increase p<0.05 in the concentration of MDA and TC levels and significant gradual decrease p<0.05 in the concentration of vitamin C with increase the duration of working in the welder group.

The effect of fruits and vegetable intakes and smoking habits on the above biochemical parameters in each group revealed significant decreases in the concentrations of MDA and TC and significant increases in the concentration of HDL-C and vitamin C p<0.05 with the increase the intake of both fruits and vegetables and give the adverse effect on both parameters due to the smoking habit in welder workers related to control subjects and to those having negative smoking habit. Conclusion : the increase in the concentrations of MDA and TC levels and the decreases in the concentration of vitamin C in welder workers with advancing age or with the increase of duration revealed that those subjects were at high risk of oxidative stress which might lead to increase the incidence of many cardiovascular and inflammatory diseases.

This effect had not been seen as soon as possible due to the increased in HDL-C level.