Role of oxidative stress by lipid peroxidation in developing urinary bladder cancer and correlation between malondialdehyde and trace elements copper and zinc

Abstract EN

This study was applied on fifty patients having urinary bladder cancer, proved by histopathological study for the biopsy taken from the bladder by cystoscopy performed under general anesthesia. In this study the type of cancer was transitional cell carcinoma of urinary bladder of different stages. In this study changes in malondieldehyde as biomarker of lipid peroxidationhave been studied the result revealed significant elevation in patient groups compared with control, and glutathione level (GSH) which considered as antioxidant defenses mechanism are significantly reduced in patients groups in comparison to control groups. The changes in level of trace elements copper and zinc are study in this work, the result revealed increase level of copper and reduced level of zinc in patients groups in comparism with control groups