Roles of malondialdehyde and catalase in serum of urolithiasis

Abstract EN

The current study is conducted to determine the level of malondialdehyde (MDA) as an index of free radicals induced lipid peroxidation and catalase as an index of antioxidant enzyme in the serum of patients with urolithiasis.

Significantly high level of MDA (p < 0.05) and significantly low level of catalase (p < 0.05) were observed in the serum of urolithiasis patients as compared to normal controls.

There was no difference in serum level of MDA and CAT between male and female neither in patients nor controls.

Also, there were no correlation between the serum MDA and serum CAT in both patients and controls.

Among patients, 21.7% were smokers.

There was no significant difference between smokers and non smokers patients regarding serum level of MDA and CAT.

In conclusion, it appears that a role of lipid peroxidation and oxidative function exists in the pathogenesis of urolithiasis, but its mechanism is unknown.