Evaluative study for the biochemical & physioloical efeects of oral contraception in Iraqi women

Abstract EN

Objective : This is study to evaluate the effects of combined oral contraception, low estrogen type on some liver function, mother physiological and biochemical characteristics of the blood.

Study design & Setting : prospective b study at Babylon medical college teaching maternity hospital, Department of Obstetric s& Gynecology, from July 2006 to June 2007.

Materials & methods : the study enrolled 330 women , attending family planning center of the hospital.

They were divided into 2 groups, The study group of 250 women (they were all pills users for a variable time), the control group of 80 healthy women (were using natural methods of contraception), Liver enzymes ALT, ALP, serum bilirubin, serum cholesterol, blood sugar, blood pressure, body mass index were compared between both group , statistical analysis was carried out using student t test, p value was calculated, any value more than 0.005 was considered not significant.

Results : The study revealed : Highly significant (p0.005) when compared with the control group, There was highly significant reduction ( p< 0.01) in HDL in the study group when compared with the control group.

There was a highly significant elevation (p<0.01) in total cholesterol for the study group when compared with the control group.

There was appositive correlation but it was non-significant between the total cholesterol, HDL level (R =0.2, P = 0.001).

There was also a highly significant elevation ( p<0.01) in the glucose level in the study group, and there is appositive correlation between the mean glucose and total cholesterol in the study group.

There is a significant increase (P

The study showed a highly significant change of body weight, an increase which is positively correlated with the body glucose.

There is a highly significant increase for both systolic and diastolic blood pressure in pills usres.

The body mass index shows a high significant increase for the study group which shows a significant correlation with the mean body weight, mean systolic blood pressure.

Conclusion: The study shows 1_The monophasic pills leads to changes in some liver function which on long term bases may leads to a disturbance in completely healthy women or risk group.

2_ the changes in body weight, blood pressure, body mass index may lead to a complication as development of of obesity and future development of diabetes in a risky group.

-3Excess morbidity related to pills especially changes in serum cholesterol, HDL, blood glucose Which may accelerate atherosclerosis ,increased coronary vasospasm, the risk is more in smokers, older women, family history of cardiovascular disease, longer duration of pills use.