Study of phagocytosis in diabetic patients

Abstract EN

This study deals with the host resistance to infection in diabetes and the influence of an acute infection on the endocrinology- metabolic status of the diabetic patient, while it is well known that acute infection lead to defecting in controlling blood sugar levels and that infection is the most frequently documented cause of ketoacidosis.

The patient with diabetes mellitus are more susceptible to infection than age and sex matched non diabetic subject “the data were being studied as phagocytic activity or (leucocytes function) to ingest bacteria (This study consist of 72 diabetic patients and 19 apparently healthy individuals.

These samples in this study have been grouped according to the severity of diabetes, duration of disease, insulin non-insulin dependent, controlled and no controlled for all Patient and control sample.

Phagocytic activity is done as well as bacterial cells per neutrophil and rate of ingestion of phagocytic cells to the bacteria among time of incubation).

The result among 72 diabetic patients showed a highly significant decreased (P<0.01) in phagocytic activity of neutrophil among this patients and direct correlation between the phagocytic activity of polymorphonucleur neutrophil (PMN) (P< 0.05) and the mean glucose level after comparison with the control samples.

The effect of duration of disease give a highly significant difference (P< 0.01) with the phagocytic activity after compares with control group as well as less than 5 years and more than 5 years.

There is a significant diminution in phagocytosis of staphylococcus aureus in subject poorly controlled diabetes in compares with the control group.

The result from these study suggest that good control of blood sugar in diabetic patient is a desirable goal in the prevention of continuous infection )Bacterial, Viral, Fungal….etc) and to ensure maintenance of normal host defense mechanism that determine resistant and response to such infections