The behavior of the plasma homocysteine and selenium concentrations in patients with acute myocardial infarction

Abstract EN

Background : Increased concentrations of plasma total homocysteine and decreased concentrations of plasma selenium are separately associated with cardiovascular disease.

Objective : Investigate the correlation between plasma total homocysteine and selenium in patients with acute myocardial infarction (AMI).

Methods: Patients of present study was thirty nine men with AMI admitted to Marburg Hospital in Marburg city, Germany on 2007.

Plasma total homocysteine was determined using HPLC.

Plasma selenium was determined using atomic absorption spectrometry.

Results : Plasma homocysteine of patients found to be increased, whereas plasma selenium found to be decreased when compared with reference range.

The correlation between plasma homocysteine and selenium found to be negatively correlated.

Conclusion : The negative correlation between plasma tHcy and selenium may indicate that they have a significant impact on the process of atherogenesis.

The change in the levels of plasma total homocysteine and plasma selenium might be result from oxidative stress associated with AMI.